J
Jesse J. Smith
Researcher at Duke University
Publications - 7
Citations - 719
Jesse J. Smith is an academic researcher from Duke University. The author has contributed to research in topics: Cytochrome c & Signal transduction. The author has an hindex of 6, co-authored 6 publications receiving 697 citations.
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Journal ArticleDOI
Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c
TL;DR: Caspase-8 promoted cytochrome c release indirectly, by cleaving at least one cytosolic substrate, potentially explaining why CD95-induced apoptosis can often evade inhibition by Bcl-2.
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Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate.
TL;DR: It is proposed that inhibition of human BPntase may account for lithium-induced nephrotoxicity, which may be overcome by supplementation of current therapeutic regimes with inhibitors of nucleotide biosynthesis, such as methionine.
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Reaper‐induced apoptosis in a vertebrate system
Erica K. Evans,Tomomi Kuwana,Susan L. Strum,Jesse J. Smith,Donald D. Newmeyer,Sally Kornbluth +5 more
TL;DR: It is shown that reaper can induce rapid apoptosis in vitro using an apoptotic reconstitution system derived from Xenopus eggs, and that a subcellular fraction enriched in mitochondria is required for this process and that reapers, acting in conjunction with cytosolic factors, can trigger mitochondrial cytochrome c release.
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Mitochondria at the crossroad of apoptotic cell death.
TL;DR: Mitochondria play a central role in apoptotic cell death, serving as a repository for cytochrome c, and it has been recently demonstrated that activated caspases cancleave key substrates to trigger mitochondrial release of cyto chrome c, thereby inducing further caspase activation and amplifying the apoptotic signal.
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Apoptotic Regulation by the Crk Adapter Protein Mediated by Interactions with Wee1 and Crm1/Exportin
Jesse J. Smith,D. Ashley Richardson,Jan Kopf,Minoru Yoshida,Robert E. Hollingsworth,Sally Kornbluth +5 more
TL;DR: It is found that a mutant Crk protein, deficient in Crm1 binding, promotes apoptosis and data suggest that a nuclear population of Crk bound to Wee1 promotes apoptotic death of mammalian cells.