J
Jessica E. Hutti
Researcher at University of North Carolina at Chapel Hill
Publications - 16
Citations - 1587
Jessica E. Hutti is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Phosphorylation & Kinase. The author has an hindex of 14, co-authored 14 publications receiving 1471 citations. Previous affiliations of Jessica E. Hutti include Beth Israel Deaconess Medical Center & Harvard University.
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Journal ArticleDOI
A rapid method for determining protein kinase phosphorylation specificity.
Jessica E. Hutti,Emily T Jarrell,James Chang,Derek W. Abbott,Peter Storz,Alex Toker,Lewis C. Cantley,Benjamin E. Turk +7 more
TL;DR: A combinatorial peptide library method that allows rapid generation of phosphorylation motifs for serine/threonine kinases is described.
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Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKKɛ Promotes Cell Transformation
Jessica E. Hutti,Rhine R. Shen,Rhine R. Shen,Derek W. Abbott,Alicia Y. Zhou,Alicia Y. Zhou,Kam Sprott,John M. Asara,John M. Asara,William C. Hahn,William C. Hahn,Lewis C. Cantley,Lewis C. Cantley,Lewis C. Cantley +13 more
TL;DR: IKKepsilon and CYLD are defined as an oncogene-tumor suppressor network that participates in tumorigenesis and phosphorylation of CYLD at serine 418 decreases its deubiquitinase activity and is necessary for IKKep silon-driven transformation.
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Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease
R. Jeremy Nichols,Nicolas Dzamko,Jessica E. Hutti,Jessica E. Hutti,Lewis C. Cantley,Lewis C. Cantley,Maria Deak,Jennifer Moran,Paul Bamborough,Alastair D. Reith,Dario R. Alessi +10 more
TL;DR: A pharmacological approach to validate whether substrates are phosphorylated by LRRK2 and use this to provide evidence that L RRK2 may not be rate-limiting for the phosphorylation of the proposed substrate moesin is described.
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Coordinated Regulation of Toll-Like Receptor and NOD2 Signaling by K63-Linked Polyubiquitin Chains
Derek W. Abbott,Yibin Yang,Jessica E. Hutti,Jessica E. Hutti,Swetha Madhavarapu,Swetha Madhavarapu,Michelle A. Kelliher,Lewis C. Cantley,Lewis C. Cantley +8 more
TL;DR: It is shown that TLR signaling requires the same ubiquitination event on NEMO to properly signal through NF-κB, and this findings suggest a biochemical mechanism for the faulty cytokine balance seen in Crohn's disease.
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IκB Kinase β Phosphorylates the K63 Deubiquitinase A20 To Cause Feedback Inhibition of the NF-κB Pathway
Jessica E. Hutti,Benjamin E. Turk,John M. Asara,Averil Ma,Lewis C. Cantley,Lewis C. Cantley,Derek W. Abbott +6 more
TL;DR: It is shown that IKKβ phosphorylates A20 in vitro and in vivo at serine 381, and it is further shown that this phosphorylation event increases the ability of A20 to inhibit the NF-κB signaling pathway.