Jessica H. Hartman

TL;DR: Methods for isolation of both mtDNA and nuclear DNA (nucDNA) and measurement of their respective copy numbers using quantitative PCR are described.

TL;DR: An acoustofluidic chip capable of rotating Caenorhabditis elegans in both static and continuous flow in a controllable manner is presented and clearly imaged the dopaminergic neurons of C. elegans with pdat-1:GFP expression, as well as the vulval muscles and muscle fibers of the worm with myo-3::GFP fusion protein expression in different orientations and three dimensions.

TL;DR: A young adult swim exercise regimen for the short-lived nematode Caenorhabditis elegans is established that induces health benefits at the neuromuscular, intestinal, and cognitive levels and protects against neurodegeneration in models of tauopathy, Alzheimer’s disease, and Huntington's disease.

TL;DR: A major, fundamental aspect of toxicological science remains underdeveloped in C. elegans: xenobiotic metabolism and transport processes that are critical to understanding toxicokinetics and toxicodynamics, and extrapolation to other species.

TL;DR: Swimming exercise and brief food deprivation provide effective intervention in Caenorhabditis elegans, protecting from age-associated mitochondrial decline and providing resistance to mitotoxicant exposures.