J
Jessica S. Crystal
Researcher at Rutgers University
Publications - 25
Citations - 3087
Jessica S. Crystal is an academic researcher from Rutgers University. The author has contributed to research in topics: Adoptive cell transfer & Melanoma. The author has an hindex of 13, co-authored 22 publications receiving 2402 citations. Previous affiliations of Jessica S. Crystal include National Institutes of Health & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
Alena Gros,Maria R. Parkhurst,Eric Tran,Anna Pasetto,Paul F. Robbins,Sadia Ilyas,Todd D. Prickett,Jared J. Gartner,Jessica S. Crystal,Ilana M. Roberts,Kasia Trebska-Mcgowan,John R. Wunderlich,James Chih-Hsin Yang,Steven A. Rosenberg +13 more
TL;DR: In this article, the authors investigated whether PD-1 expression on peripheral blood lymphocytes could be used as a biomarker to detect T cells that target neoantigens, using a high-throughput personalized screening approach, identifying neoantigen-specific lymphocytes in the peripheral blood of three of four melanoma patients.
Journal ArticleDOI
A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response
Paul F. Robbins,Sadik H. Kassim,Thai Lan N. Tran,Jessica S. Crystal,Richard A. Morgan,Steven A. Feldman,James Chih-Hsin Yang,Mark E. Dudley,John R. Wunderlich,Richard M. Sherry,Udai S. Kammula,Michael S. Hughes,Nicholas P. Restifo,Mark Raffeld,Chyi-Chia Richard Lee,Yong F. Li,Mona El-Gamil,Steven A. Rosenberg +17 more
TL;DR: The adoptive transfer of autologous T cells transduced with a retrovirus encoding a TCR against an HLA-A*0201 restricted NY-ESO-1 epitope can be an effective therapy for some patients bearing synovial cell sarcomas and melanomas that are refractory to other treatments.
Journal ArticleDOI
Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions
Yong-Chen Lu,Xin Yao,Jessica S. Crystal,Yong F. Li,Mona El-Gamil,Colin A. Gross,Lindy Davis,Mark E. Dudley,James Chih-Hsin Yang,Yardena Samuels,Steven A. Rosenberg,Paul F. Robbins +11 more
TL;DR: Findings suggest that the minigene screening approach can facilitate the antigen repertoire analysis of tumor reactive T cells, and lead to the development of new adoptive cell therapies with purified T cells that recognize candidate-mutated antigens derived from genes essential for the carcinogenesis.
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Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes
Cyrille J. Cohen,Cyrille J. Cohen,Jared J. Gartner,Miryam Horovitz-Fried,Katerina Shamalov,Kasia Trebska-Mcgowan,Valery Bliskovsky,Maria R. Parkhurst,Chen Ankri,Todd D. Prickett,Jessica S. Crystal,Yong F. Li,Mona El-Gamil,Steven A. Rosenberg,Paul F. Robbins +14 more
TL;DR: To the best of the knowledge, this represents the first demonstration of the successful isolation of mutation-reactive T cells from patients' peripheral blood prior to immune therapy, potentially providing the basis for designing personalized immunotherapies to treat patients with advanced cancer.
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The public health burden of emergency general surgery in the United States: A 10-year analysis of the Nationwide Inpatient Sample--2001 to 2010.
TL;DR: The burden of disease for emergency general surgery in the United States is substantial and is increasing, and data can be used to guide future research into improved access to care, resource allocation, and quality improvement efforts.