J
Jhon-Jairo Sutachan
Researcher at Pontifical Xavierian University
Publications - 19
Citations - 575
Jhon-Jairo Sutachan is an academic researcher from Pontifical Xavierian University. The author has contributed to research in topics: Neuroprotection & Cancer. The author has an hindex of 10, co-authored 17 publications receiving 481 citations. Previous affiliations of Jhon-Jairo Sutachan include Fordham University & New York University.
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Journal ArticleDOI
Effects of natural antioxidants in neurodegenerative disease
Sonia Luz Albarracín,Ben Stab,Zulma Casas,Jhon-Jairo Sutachan,Ismael Samudio,Janneth Gonzalez,Luis Gonzalo,Francisco Capani,Ludis Morales,George E. Barreto +9 more
TL;DR: The aim of this paper is to present various well-known dietary polyphenols and their mechanisms of neuroprotection with an emphasis on Alzheimer’s disease, Parkinson's disease, and amyotrophic lateral sclerosis.
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Cellular and molecular mechanisms of antioxidants in Parkinson's disease
Jhon-Jairo Sutachan,Zulma Casas,Sonia Luz Albarracín,Bernd Robert Stab,Ismael Samudio,Janneth Gonzalez,Ludis Morales,George E. Barreto +7 more
TL;DR: The mechanisms by which polyphenols and endogenous antioxidants can produce protection against oxidative stress are reviewed, including: scavenging nitrogen and oxygen reactive species, regulation of signaling pathways associated with cell survival and inflammation, and inhibition of synphilin-1 and alpha-synuclein aggregation.
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Connexin-Mediated Functional and Metabolic Coupling Between Astrocytes and Neurons.
TL;DR: This review will focus on molecular mechanisms mediating physiological and pathological coupling between astrocytes and neurons through GJs and HCs.
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TRP Channels Role in Pain Associated With Neurodegenerative Diseases.
Milena Duitama,Viviana Vargas-López,Zulma Casas,Sonia Luz Albarracín,Jhon-Jairo Sutachan,Yolima P. Torres +5 more
TL;DR: The TRP-dependent mechanism that can mediate pain sensation in neurodegenerative diseases and the therapeutic approach available to palliate pain and neurodegenersative symptoms throughout the regulation of these channels are described.
Journal ArticleDOI
Role of Connexins 30, 36, and 43 in Brain Tumors, Neurodegenerative Diseases, and Neuroprotection
Oscar F. Sánchez,Andrea V Rodriguez,José M Velasco-España,Laura C Murillo,Jhon-Jairo Sutachan,Sonia-Luz Albarracin +5 more
TL;DR: The role of GJs and Cxs in glioblastoma, Alzheimer's, Parkinson's, and Huntington's diseases, and neuroprotection are analyzed with the aim of shedding light in the possibility of using Cx regulators as potential therapeutic molecules.