J
Ji Hyeon Ju
Researcher at Catholic University of Korea
Publications - 226
Citations - 6319
Ji Hyeon Ju is an academic researcher from Catholic University of Korea. The author has contributed to research in topics: Arthritis & Induced pluripotent stem cell. The author has an hindex of 40, co-authored 212 publications receiving 5172 citations. Previous affiliations of Ji Hyeon Ju include Dongguk University & St Mary's Hospital.
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STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice
Mi La Cho,Jung Won Kang,Young Mee Moon,Hyo Jung Nam,Joo Yeon Jhun,Seong Beom Heo,Hyun Tak Jin,So Youn Min,Ji Hyeon Ju,Kyung Su Park,Young Gyu Cho,Chong Hyeon Yoon,Sung Hwan Park,Young Chul Sung,Ho-Youn Kim +14 more
TL;DR: The data suggest that IL-23 seems to be a central proinflammatory cytokine in the pathogenesis of this IL-1Ra−/− model of spontaneous arthritis, and its intracellular signaling pathway could be useful therapeutic targets in the treatment of autoimmune arthritis.
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Hyaluronate–Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis
Hwiwon Lee,Min-Young Lee,Suk Ho Bhang,Byung-Soo Kim,Yun Seop Kim,Ji Hyeon Ju,Ki Su Kim,Sei Kwang Hahn +7 more
TL;DR: The therapeutic effect of HA-AuNP/TCZ complex on RA was confirmed in collagen-induced arthritis (CIA) model mice by ELISA, histological, and Western blot analyses.
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Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation
Kyoung Woon Kim,Mi La Cho,Sang-Heon Lee,Hye Joa Oh,Chang Min Kang,Ji Hyeon Ju,So Youn Min,Young Gyu Cho,Sung Hwan Park,Ho-Youn Kim +9 more
TL;DR: The results suggest that the TLR signaling pathway, through TLR-2 andTLR-4, induces RANKL expression in RA-FLS and the expression of RankL promotes the differentiation of osteoclasts in RA synovium.
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IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients
Yu-Jung Heo,Young-Bin Joo,Hye-Jwa Oh,Mi-Kyung Park,Yang-Mi Heo,Mi-La Cho,Seung-Ki Kwok,Ji Hyeon Ju,Kyung-Su Park,Seok-Goo Cho,Sung-Hwan Park,Ho-Youn Kim,Jun-Ki Min +12 more
TL;DR: IT treatment significantly decreased the numbers of IL-17-producing and RORc-expressing cells among human CD4(+) T cells that had been activated in vitro by Th17-differentiating conditions in autoimmune arthritis patients.
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Up-regulation of stromal cell–derived factor 1 (CXCL12) production in rheumatoid synovial fibroblasts through interactions with T lymphocytes: Role of interleukin-17 and CD40L–CD40 interaction
Kyoung-Woon Kim,Mi-La Cho,Hae-Rim Kim,Ji Hyeon Ju,Mi-Kyung Park,Hye-Jwa Oh,Joon Seok Kim,Sung-Hwan Park,Sang-Heon Lee,Ho-Youn Kim +9 more
TL;DR: SDF- 1 is overproduced in RA FLS, and IL-17 could up-regulate the expression of SDF-1 in RAFLS via pathways mediated by PI 3-kinase, NF-kappaB, and AP-1, and the findings suggest that inhibition of the interaction between T cells and SDF -1 in FLS may provide a new therapeutic approach in RA.