S
Sang-Heon Lee
Researcher at Konkuk University
Publications - 140
Citations - 4163
Sang-Heon Lee is an academic researcher from Konkuk University. The author has contributed to research in topics: RANKL & Arthritis. The author has an hindex of 34, co-authored 136 publications receiving 3547 citations. Previous affiliations of Sang-Heon Lee include Catholic University of Korea & St Mary's Hospital.
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Journal ArticleDOI
Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study
Mark C. Genovese,Patrick Durez,Hanno B. Richards,Jerzy Supronik,Eva Dokoupilova,Mazurov Vi,Jacob A. Aelion,Sang-Heon Lee,Christine E Codding,Herbert Kellner,Takashi Ikawa,Sophie Hugot,Shephard Mpofu +12 more
TL;DR: The safety profile of secukinumab was consistent with that seen with other biological agents, and most adverse events (AE) were mild to moderate in severity, and there were no unexpected safety signals and no specific organ-related toxicities.
Journal ArticleDOI
Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial
Désirée van der Heijde,James Cheng-Chung Wei,Maxime Dougados,Philip J. Mease,Atul Deodhar,Walter P. Maksymowych,Filip Van den Bosch,Joachim Sieper,Tetsuya Tomita,Robert Landewé,Fangyi Zhao,Eswar Krishnan,David H. Adams,Beth A. Pangallo,Hilde Carlier,Melvin Churchill,Kathleen P. Flint,Geoffrey Gladstein,Maria Greenwald,Mary P. Howell,Akgun Ince,Jeffrey L. Kaine,Daksha Mehta,Eric A. Peters,Roel Querubin,John D. Reveille,Richard Roseff,Roger J. Diegel,Christine Thai,Louis Bessette,Frederic Morin,Proton Rahman,Aaron Alejandro Barrera Rodriguez,Fidencio Cons-Molina,Sergio Duran Barragan,Cassandra M. Skinner,Cesar Francisco Pacheco Tena,Cesar Ricardo Ramos Remus,Juan Cruz Rizo Rodriguez,Seung-Jae Hong,Yeon-Ah Lee,Ji Hyeon Ju,Seong Wook Kang,Tae-Hwan Kim,Chang Keun Lee,Eun Bong Lee,Sang-Heon Lee,Min Chan Park,Kichul Shin,Sang-Hoon Lee,Hung-An Chen,Ying-Chou Chen,Song-Chou Hsieh,Joung-Liang Lan,Zdenek Dvorak,Radka Moravcova,Martina Malcova,Yoshinori Taniguchi,Mitsumasa Kishimoto,Kurisu Tada,Hiroaki Dobashi,Kentaro Inui,Yukitaka Ueki,Yoshifuji Matsumoto,Yoshinobu Koyama,Kazuhiro Hatta,Tatsuya Atsumi,Hitoshi Goto,Kiyoshi Matsui,Yuya Takakubo,Gunther Neeck,Denis Poddubnyy,Andrea Rubbert-Roth,Malgorzata Szymanska,Tomasz Blicharski,Anna Dudek,Artur Racewicz,Rafal Wojciechowski,Marleen G H van de Sande,Ed Griep,Michael T. Nurmohamed,Galina Matsievskaya,Evgeniya Shmidt,Marina Stanislav,Sergey Yakushin,Olga Ershova,A P Rebrov,Tibor Balazs,Regina Cseuz,E. Drescher,Gyula Poor +90 more
TL;DR: Each dosing regimen of ixekizumab was superior to placebo for improving radiographic axial spondyloarthritis signs and symptoms in patients not previously treated with bDMARDs; the safety profile was consistent with previous indications of IXekzumab.
Journal ArticleDOI
Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts
Kyoung-Woon Kim,Hae-Rim Kim,Jin-Young Park,Jin-Sil Park,Hye-Jwa Oh,Yun-Ju Woo,Mi-Kyung Park,Mi-La Cho,Sang-Heon Lee +8 more
TL;DR: Results show that IL-22 up-regulates RANKL expression in RA synovial fibroblasts and induces osteoclastogenesis, mediated by the p38 MAPK/NF-κB and JAK-2/STAT-3 signaling pathways.
Journal ArticleDOI
Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood
Uk Yeol Moon,Su Jin Park,Sang Taek Oh,Wan-Uk Kim,Sung-Hwan Park,Sang-Heon Lee,Chul-Soo Cho,Ho-Youn Kim,Won-Keun Lee,Suk Kyeong Lee +9 more
TL;DR: Interestingly, the EBV burden in peripheral blood mononuclear cells (PBMCs) was over 15-fold greater in SLE patients than in healthy control individuals, suggesting that EBV infection is abnormally regulated in S LE.
Journal ArticleDOI
Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation
Kyoung Woon Kim,Mi La Cho,Sang-Heon Lee,Hye Joa Oh,Chang Min Kang,Ji Hyeon Ju,So Youn Min,Young Gyu Cho,Sung Hwan Park,Ho-Youn Kim +9 more
TL;DR: The results suggest that the TLR signaling pathway, through TLR-2 andTLR-4, induces RANKL expression in RA-FLS and the expression of RankL promotes the differentiation of osteoclasts in RA synovium.