J
Ji-Yang Wang
Researcher at Fudan University
Publications - 64
Citations - 2009
Ji-Yang Wang is an academic researcher from Fudan University. The author has contributed to research in topics: B cell & Antibody. The author has an hindex of 20, co-authored 64 publications receiving 1653 citations. Previous affiliations of Ji-Yang Wang include Kyushu University & Tokyo Medical and Dental University.
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Journal ArticleDOI
Identity of the elusive IgM Fc receptor (FcμR) in humans
Hiromi Kubagawa,Satoshi Oka,Yoshiki Kubagawa,Ikuko Torii,Eiji Takayama,Dong-Won Kang,G. Larry Gartland,Luigi F. Bertoli,Hiromi Mori,Hiroyuki Takatsu,Toshio Kitamura,Hiroshi Ohno,Ji-Yang Wang +12 more
TL;DR: The results indicate that FcμR per se has no inhibitory activity in Fas-mediated apoptosis and that such inhibition is only achieved when anti-Fas antibody of an IgM but not IgG isotype is used for inducing apoptosis.
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Discriminating gene expression profiles of memory B cell subpopulations
Götz R. A. Ehrhardt,Atsushi Hijikata,Hiroshi Kitamura,Osamu Ohara,Ji-Yang Wang,Max D. Cooper +5 more
TL;DR: This recently identified subpopulation of BMem cells, which normally resides in epithelial tissue-based niches, may serve a unique role in mucosal defense and, conversely, as a target for neoplastic transformation events.
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Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells
Takashi Imai,Yu Kato,Chiaki Kajiwara,Shusaku Mizukami,Ikuo Ishige,Tomoko Ichiyanagi,Masaki Hikida,Ji-Yang Wang,Heiichiro Udono +8 more
TL;DR: It is demonstrated that heat shock protein 90 (HSP90) is critical for cross-presentation by pulling endosomal Ag out into the cytosol in a process abrogated by the HSP90 inhibitor.
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Identification of TOSO/FAIM3 as an Fc receptor for IgM
Hideaki Shima,Hiroyuki Takatsu,Shinji Fukuda,Masumi Ohmae,Koji Hase,Hiromi Kubagawa,Ji-Yang Wang,Hiroshi Ohno +7 more
TL;DR: The results identify TOSO/FAIM3 as a receptor for IgM and suggest that FcmuR may serve as an uptake receptorFor IgM-opsonized antigens by B cells.
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Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses
Rika Ouchida,Hiromi Mori,Koji Hase,Hiroyuki Takatsu,Tomohiro Kurosaki,Takeshi Tokuhisa,Hiroshi Ohno,Ji-Yang Wang +7 more
TL;DR: A unique pathway mediated by the FcμR for regulating immunity and tolerance is defined and it is suggested that IgM antibodies promote humoral immune responses to foreign antigen yet suppress autoantibody production through at least two pathways: complement activation and Fc μR.