Jia Tsrong Jan

TL;DR: A cell-based assay was developed to screen existing drugs, natural products, and synthetic compounds to identify effective anti-SARS agents, and of particular interest are the two anti-HIV agents, one as an entry blocker and the other as a 3CL protease inhibitor.

TL;DR: It is suggested that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects.

TL;DR: In this paper, the authors used a cell-based infection assay to screen more than 3,000 agents used in humans and animals, including 2,855 small molecules and 190 traditional herbal medicines, and identified 15 active small molecules in concentrations ranging from 0.1 nM to 50 μM.

TL;DR: In this article, serological and plasmablast response was detected within 3 weeks of onset of SARS-CoV-2 infection in all patients and the serological titre was elicited soon after or concomitantly with peripheral PLB response.

TL;DR: Oseltamivir phosphonic acid, its mono methyl ester, guanidino-tamiphosphor, and its monoethyl ester are potent inhibitors of influenza neuraminidases that inhibit the replication of influenza viruses at low nanomolar to picomolar levels, and significantly protect mice from infection with lethal doses of influenza virus when orally administered with 1 mg/kg or higher doses.