Jialin Chen

TL;DR: The aligned electrospun nanofiber structure provides an instructive microenvironment for hTSPC differentiation and may lead to the development of desirable engineered tendons.

TL;DR: Tissue-engineered tendon can be successfully fabricated through seeding of hESC-MSCs within a knitted silk-collagen sponge scaffold followed by mechanical stimulation, and cell labeling and extracellular matrix expression assays demonstrated that the transplants not only contributed directly to tendon regeneration, but also exerted an environment-modifying effect on the implantation site in situ.

TL;DR: In this paper, a silk fibroin film is developed and its translational potential is investigated for skin repair by performing comprehensive preclinical and clinical studies to fully evaluate its safety and effectiveness.

TL;DR: A bioactive scaffold is developed by incorporation of exogenous SDF-1 alpha within a knitted silk-collagen sponge scaffold to enable selective migration and homing of cells for in situ tendon regeneration and improved efficacy of tendon regeneration by increasing the recruitment of fibroblast-like cells, enhancing local endogenous SDF1 alpha and tendon extracellular matrix production, and decreasing accumulation of inflammatory cells.

TL;DR: Creating an in situ matrix environment conducive to C-MSCs and SM- MSCs migration and adhesion with col1 scaffold containing SDF-1 can be exploited to improve self-repair capacity of cartilage.