Using artificial intelligence (AI) to prevent and treat diseases is an ultimate goal in computational medicine. Although AI has been developed for screening and assisted decision-making in disease prevention and management, it has not yet been validated for systematic application in the clinic. In the context of rare diseases, the main strategy has been to build specialized care centres; however, these centres are scattered and their coverage is insufficient, which leaves a large proportion of rare-disease patients with inadequate care. Here, we show that an AI agent using deep learning, and involving convolutional neural networks for diagnostics, risk stratification and treatment suggestions, accurately diagnoses and provides treatment decisions for congenital cataracts in an in silico test, in a website-based study, in a ‘finding a needle in a haystack’ test and in a multihospital clinical trial. We also show that the AI agent and individual ophthalmologists perform equally well. Moreover, we have integrated the AI agent with a cloud-based platform for multihospital collaboration, designed to improve disease management for the benefit of patients with rare diseases. An artificial intelligence agent integrated with a cloud-based platform for multihospital collaboration performs equally as well as ophthalmologists in the diagnosis of congenital cataracts in a series of online tests and a multihospital clinical trial.

An artificial intelligence platform for the multihospital collaborative management of congenital cataracts

Automated classification of Pap smear images to detect cervical dysplasia

The lifestyle of modern society has changed significantly with the emergence of artificial intelligence (AI), machine learning (ML), and deep learning (DL) technologies in recent years. Artificial intelligence is a multidimensional technology with various components such as advanced algorithms, ML and DL. Together, AI, ML, and DL are expected to provide automated devices to ophthalmologists for early diagnosis and timely treatment of ocular disorders in the near future. In fact, AI, ML, and DL have been used in ophthalmic setting to validate the diagnosis of diseases, read images, perform corneal topographic mapping and intraocular lens calculations. Diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma are the 3 most common causes of irreversible blindness on a global scale. Ophthalmic imaging provides a way to diagnose and objectively detect the progression of a number of pathologies including DR, AMD, glaucoma, and other ophthalmic disorders. There are 2 methods of imaging used as diagnostic methods in ophthalmic practice: fundus digital photography and optical coherence tomography (OCT). Of note, OCT has become the most widely used imaging modality in ophthalmology settings in the developed world. Changes in population demographics and lifestyle, extension of average lifespan, and the changing pattern of chronic diseases such as obesity, diabetes, DR, AMD, and glaucoma create a rising demand for such images. Furthermore, the limitation of availability of retina specialists and trained human graders is a major problem in many countries. Consequently, given the current population growth trends, it is inevitable that analyzing such images is time-consuming, costly, and prone to human error. Therefore, the detection and treatment of DR, AMD, glaucoma, and other ophthalmic disorders through unmanned automated applications system in the near future will be inevitable. We provide an overview of the potential impact of the current AI, ML, and DL methods and their applications on the early detection and treatment of DR, AMD, glaucoma, and other ophthalmic diseases.

Promising Artificial Intelligence-Machine Learning-Deep Learning Algorithms in Ophthalmology.

With the emergence of unmanned plane, autonomous vehicles, face recognition, and language processing, the artificial intelligence (AI) has remarkably revolutionized our lifestyle. Recent studies indicate that AI has astounding potential to perform much better than human beings in some tasks, especially in the image recognition field. As the amount of image data in imaging center of ophthalmology is increasing dramatically, analyzing and processing these data is in urgent need. AI has been tried to apply to decipher medical data and has made extraordinary progress in intelligent diagnosis. In this paper, we presented the basic workflow for building an AI model and systematically reviewed applications of AI in the diagnosis of eye diseases. Future work should focus on setting up systematic AI platforms to diagnose general eye diseases based on multimodal data in the real world.

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Applications of Artificial Intelligence in Ophthalmology: General Overview

The blood vessels are the primary anatomical structure that can be visible in retinal images. The segmentation of retinal blood vessels has been accepted worldwide for the diagnosis of both cardiovascular (CVD) and retinal diseases. Thus, it requires an appropriate vessel segmentation method for automatic detection of retinal diseases such as diabetic retinopathy and cataract. The detection of retinal diseases using computer-aided diagnosis (CAD) can help people to avoid the risks of visual impairment and save medical resources. This survey presents a comparative analysis of various machine learning and deep learning-based methods for automated blood vessel segmentation in retinal images. This paper briefly describes fundus photography, publicly available retinal databases, pre-processing and post-processing techniques for retinal vessels segmentation. A comprehensive review of the state of the art supervised and unsupervised blood vessel segmentation methodologies are presented in this paper. The objective of this study is to establish a professional structure to familiarize an individual with up-to-date vessel segmentation techniques. Moreover, we compared these approaches to the dataset, evaluation metrics, pre-processing and post-processing steps, feature extraction, segmentation methods, and induced results.

/pdf/comparative-analysis-of-vessel-segmentation-techniques-in-4ow2236fbr.pdf

Jian He

Papers

Exploiting ensemble learning for automatic cataract detection and grading