B
Bochuan Li
Researcher at Tianjin Medical University
Publications - 14
Citations - 745
Bochuan Li is an academic researcher from Tianjin Medical University. The author has contributed to research in topics: Endothelial activation & Endothelium. The author has an hindex of 8, co-authored 12 publications receiving 442 citations.
Papers
More filters
Journal ArticleDOI
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow
Li Wang,Jiang-Yun Luo,Bochuan Li,Xiao Yu Tian,Li-Jing Chen,Yuhong Huang,Jian Liu,Dan Deng,Chi Wai Lau,Song Wan,Ding Ai,Kinglun Kingston Mak,Ka Kui Tong,Kin Ming Kwan,Nanping Wang,Jeng-Jiann Chiu,Yi Zhu,Yu Huang +17 more
TL;DR: The results indicate that integrin–Gα13–RhoA–YAP pathway holds promise as a novel drug target against atherosclerosis.
Journal ArticleDOI
Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells.
Jinlong He,Qiankun Bao,Yan Zhang,Mingming Liu,Huizhen Lv,Yajin Liu,Liu Yao,Bochuan Li,Chenghu Zhang,Shuang He,Guijin Zhai,Yan Zhu,Xin Liu,Kai Zhang,Xiu-Jie Wang,Ming-Hui Zou,Yi Zhu,Ding Ai +17 more
TL;DR: In this article, the effect of EC YAP on angiogenesis and its underlying mechanisms was investigated using Tie2Cre-mediated YAP transgenic (Tie2C-YAP Tg ) mice.
Journal ArticleDOI
c-Abl regulates YAP Y357 phosphorylation to activate endothelial atherogenic responses to disturbed flow
TL;DR: The c-Abl/YAPY357 pathway serves as a mechanism for the activation of integrin &agr;5&bgr;1 and the atherogenic phenotype of ECs in response to OSS, and provides a potential therapeutic strategy for atherogenesis.
Journal ArticleDOI
Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation.
Chenghu Zhang,Ting Zhou,Zhipeng Chen,Meng Yan,Bochuan Li,Huizhen Lv,Huizhen Lv,Chunjiong Wang,Song Xiang,Lei Shi,Lei Shi,Yi Zhu,Ding Ai,Ding Ai +13 more
TL;DR: The data elucidate a novel endothelial mechanotransduction molecular mechanism linking atheroprone flow and activation of integrin α5β1, thereby identifying a class of potential therapeutic targets for atherosclerosis.
Journal ArticleDOI
Regulation of YAP by Mammalian Target of Rapamycin Complex 1 in Endothelial Cells Controls Blood Pressure Through COX-2/mPGES-1/PGE 2 Cascade.
Liu Yao,Jinlong He,Bochuan Li,Meng Yan,Hui Wang,Lu Tan,Mingming Liu,Xue Lv,Huizhen Lv,Xu Zhang,Chen Chen,Dao Wen Wang,Ying Yu,Yu Huang,Yi Zhu,Ding Ai +15 more
TL;DR: In this paper, the role of endothelial mTORC1 activity in hypertension was investigated in tethered-2-caused heterozygous-deficient (Tie2Cre-RaptorKD) mice.