K
Kin Ming Kwan
Researcher at The Chinese University of Hong Kong
Publications - 52
Citations - 3090
Kin Ming Kwan is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Cerebellum & Medicine. The author has an hindex of 23, co-authored 46 publications receiving 2676 citations. Previous affiliations of Kin Ming Kwan include University of Texas MD Anderson Cancer Center & Baylor College of Medicine.
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Journal ArticleDOI
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow
Li Wang,Jiang-Yun Luo,Bochuan Li,Xiao Yu Tian,Li-Jing Chen,Yuhong Huang,Jian Liu,Dan Deng,Chi Wai Lau,Song Wan,Ding Ai,Kinglun Kingston Mak,Ka Kui Tong,Kin Ming Kwan,Nanping Wang,Jeng-Jiann Chiu,Yi Zhu,Yu Huang +17 more
TL;DR: The results indicate that integrin–Gα13–RhoA–YAP pathway holds promise as a novel drug target against atherosclerosis.
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Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
Akio Kobayashi,Kin Ming Kwan,Thomas L. Carroll,Andrew P. McMahon,Cathy Mendelsohn,Richard R. Behringer,Richard R. Behringer +6 more
TL;DR: It is demonstrated that the nephric duct is essential for the elongation and maintenance of the adjacent Müllerian duct, the anlage of the female reproductive tract, and that Lim1 functions in distinct tissue compartments of the developing metanephros for both proper development of the ureteric buds and the patterns of renal vesicles for nephron formation.
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Abnormal Compartmentalization of Cartilage Matrix Components in Mice Lacking Collagen X: Implications for Function
Kin Ming Kwan,Michael K.M. Pang,Sheila Zhou,Soot Keng Cowan,Richard Y.C. Kong,Tim Pfordte,Bjorn R. Olsen,David Sillence,Patrick P.L. Tam,Kathryn S.E. Cheah +9 more
TL;DR: It is proposed that collagen X plays a role in the normal distribution of matrix vesicles and proteoglycans within the growth plate matrix, which would accommodate the previously conflicting views of the function of collagen X and of the molecular pathogenesis of SMCD.
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Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function
Kwok Yeung Tsang,Danny Chan,Deborah Cheslett,Wilson C.W. Chan,Chi Leong So,Ian G. Melhado,Tori W. Y Chan,Kin Ming Kwan,Ernst B. Hunziker,Yoshihiko Yamada,John F. Bateman,John F. Bateman,Kenneth M.C. Cheung,Kathryn S.E. Cheah +13 more
TL;DR: Altered differentiation in terminally differentiating hypertrophic chondrocytes expressing unfolded or misfolded proteins may be part of an adaptive response that facilitates survival and recovery from the ensuing ER stress, however, the altered differentiation disrupts the highly coordinated events of endochondral ossification culminating in chondrodysplasia.
Journal ArticleDOI
Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse
William Shawlot,Maki Wakamiya,Kin Ming Kwan,Artur Kania,Thomas M. Jessell,Richard R. Behringer +5 more
TL;DR: It is indicated that Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation and that its inactivation in these tissues produces cell non-autonomous defects.