Jian-Ying Song

TL;DR: Wang et al. as discussed by the authors designed, synthesized and evaluated as tubulin polymerization inhibitors targeting the colchicine binding site, and showed that compound MY-413 was a promising lead compound for the further investigation as a potential anti-gastric cancer agent.

TL;DR: In this article , N-benzylarylamide saderivatives were designed and synthesized, and their antiproliferative activities were explored, and 51 target compounds exhibited potent inhibitory activities against MGC-803, HCT-116 and KYSE450 cells with IC50 values in two-digit nanomolar.

TL;DR: Wang et al. as discussed by the authors reported a novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo.

TL;DR: Two unsymmetrical tetradentate macrocycles, incorporating sp2 and sp3 nitrogens as donor sites and with donor group-bearing side arms attached to the sp3 nitrogen atoms, La and Lb, and their complexes with different kinds of metal cations such as Na+, Cu2+, Co2+, Ni2+, Hg2+ and Cd2+, were synthesized and characterized by elemental analysis, IR, UV and 1H NMR spectroscopy.

TL;DR: In this paper , the authors reviewed the structure and biological functions of VEGFR-2 and summarized the drug discovery strategies, and inhibitory activities of multiple VEG-2 inhibitors with multi-targeting capabilities reported in recent years.