Xin-Yi Tian

TL;DR: In this article, the structure and biological function of FAK are reviewed, and the design, chemical types, and activity of the FAK drugs are summarized according to the development of drugs, which provided the reference for the discovery of new anticancer agents.

TL;DR: Wang et al. as discussed by the authors designed, synthesized and evaluated as tubulin polymerization inhibitors targeting the colchicine binding site, and showed that compound MY-413 was a promising lead compound for the further investigation as a potential anti-gastric cancer agent.

TL;DR: In this article , N-benzylarylamide saderivatives were designed and synthesized, and their antiproliferative activities were explored, and 51 target compounds exhibited potent inhibitory activities against MGC-803, HCT-116 and KYSE450 cells with IC50 values in two-digit nanomolar.

TL;DR: NEDDylation promotion induced by compound K3 is reported, which could inhibit the cancer cell lines MGC-803 and HGC-27 and induce thecancer cell apoptosis via prompting the degradation of c-IAP and YAP/TAZ.

TL;DR: Wang et al. as discussed by the authors reported a novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo.