J
Jian Zuo
Researcher at Creighton University
Publications - 138
Citations - 6982
Jian Zuo is an academic researcher from Creighton University. The author has contributed to research in topics: Cochlea & Hair cell. The author has an hindex of 42, co-authored 128 publications receiving 6014 citations. Previous affiliations of Jian Zuo include Howard Hughes Medical Institute & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.
TL;DR: It is shown that targeted deletion of prestin in mice results in loss of outer hair cell electromotility in vitro and a 40–60 dB loss of cochlear sensitivity in vivo, without disruption of mechano-electrical transduction in outer hair cells.
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Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification
Peter Dallos,Xudong Wu,Mary Ann Cheatham,Jiangang Gao,Jing Zheng,Charles T. Anderson,Shuping Jia,Xiang Wang,Wendy H.Y. Cheng,Soma Sengupta,David Z.Z. He,Jian Zuo +11 more
TL;DR: This work studies a mouse model without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduction, but with diminished prestin function, demonstrating that prestin-based electromotility is required for cochlear amplification.
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Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea
Renjie Chai,Bryan Kuo,Tian Wang,Eric J. Liaw,Anping Xia,Taha A. Jan,Zhiyong Liu,Makoto Mark Taketo,John S. Oghalai,Roeland Nusse,Jian Zuo,Alan G. Cheng +11 more
TL;DR: It is suggested that Lgr5 marks sensory precursors and that Wnt signaling can promote their proliferation and provide mechanistic insights into Wnt-responsive progenitor cells during sensory organ development.
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Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo
Brandon C. Cox,Renjie Chai,Renjie Chai,Anne Lenoir,Anne Lenoir,Zhiyong Liu,Zhiyong Liu,Lingli Zhang,Duc-Huy Nguyen,Kavita Chalasani,Katherine A. Steigelman,Katherine A. Steigelman,Jie Fang,Edwin W. Rubel,Alan G. Cheng,Jian Zuo +15 more
TL;DR: It is demonstrated that the neonatal mouse cochlea is capable of spontaneous hair cell regeneration after damage in vivo, which might shed light on the competence of supporting cells to regenerate hair cells and on the factors that promote the survival of newly regenerated hair cells.
Journal ArticleDOI
Purkinje cell degeneration (pcd) Phenotypes Caused by Mutations in the Axotomy-Induced Gene, Nna1
Angeles Fernandez-Gonzalez,Albert R. La Spada,Jason Treadaway,Jason C. Higdon,Belinda S. Harris,Richard L. Sidman,James I. Morgan,Jian Zuo +7 more
TL;DR: The present study suggests an unexpected molecular link between neuronal degeneration and regeneration, and its results have potential implications for neurodegenerative diseases and male infertility.