J
Jiangang Gao
Researcher at Shandong University
Publications - 78
Citations - 2937
Jiangang Gao is an academic researcher from Shandong University. The author has contributed to research in topics: Hair cell & Cochlea. The author has an hindex of 22, co-authored 66 publications receiving 2509 citations. Previous affiliations of Jiangang Gao include St. Jude Children's Research Hospital.
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Journal ArticleDOI
Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.
TL;DR: It is shown that targeted deletion of prestin in mice results in loss of outer hair cell electromotility in vitro and a 40–60 dB loss of cochlear sensitivity in vivo, without disruption of mechano-electrical transduction in outer hair cells.
Journal ArticleDOI
Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification
Peter Dallos,Xudong Wu,Mary Ann Cheatham,Jiangang Gao,Jing Zheng,Charles T. Anderson,Shuping Jia,Xiang Wang,Wendy H.Y. Cheng,Soma Sengupta,David Z.Z. He,Jian Zuo +11 more
TL;DR: This work studies a mouse model without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduction, but with diminished prestin function, demonstrating that prestin-based electromotility is required for cochlear amplification.
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Cochlear function in Prestin knockout mice
TL;DR: Data support the idea that forward transduction is not degraded in OHCs lacking prestin, and frequency selectivity in CAP tuning curves recorded in homozygotes is demonstrated.
Journal ArticleDOI
A review of current large-scale mouse knockout efforts.
TL;DR: The knockout mouse project (KOMP) and the international gene trap consortium (IGTC) were initiated to create convenient resources for scientific research worldwide and knock out all the mouse genes.
Journal ArticleDOI
Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene.
Jiangang Gao,Kyeongmi Cheon,Steven Nusinowitz,Qin Liu,Di Bei,Karen Atkins,Asif Azimi,Stephen P. Daiger,Debora B. Farber,John R. Heckenlively,Eric A. Pierce,Lori S. Sullivan,Jian Zuo +12 more
TL;DR: It is demonstrated that Rp1 is required for normal morphogenesis of photoreceptor outer segments and also may play a role in rhodopsin transport to the outer segments in RP1 mice.