Jianfeng Du

TL;DR: It is demonstrated that cardiac function was depressed in diabetic mice, but HDAC inhibition resulted in a significant functional improvement in STZ-injected mice, and myocardial superoxide dismutase, an important antioxidant, was elevated followingHDAC inhibition in the diabetic mice.

TL;DR: Irisin serves as a novel approach to eliciting cardioprotection, which is associated with the improvement of mitochondrial function and significantly attenuated hypoxia/reoxygenation (H/R), as indicated by the reduction of lactate dehydrogenase (LDH) leakage and apoptotic cardiomyocytes.

TL;DR: It is suggested that HDAC inhibition plays a critical role to preserve cardiac performance and mitigate metabolic disorders in obesity and diabetes, which is associated with MKK3/p38/PRAK pathway.

TL;DR: In this article, the authors demonstrated that GLP-1R with exendin-4 improved myocardial functional recovery in acute myocardious ischemic injury. But, they did not investigate whether GLP1R can improve the functional recovery.

TL;DR: Mouse myocardial infarction was created to assess the effect of HDAC4 inhibition in c-kit(+) CSCs on myocardIAL regeneration in vivo when cells were introduced into MI hearts, and results indicate that HDAC 4 inhibition promotes CSC-derived cardiac regeneration and improves the restoration of cardiac function.