Xiaojing Yan

TL;DR: The results demonstrate for the first time that the phosphorylation of ATG4B at Ser34 participates in the metabolic reprogramming of HCC cells via repressing mitochondrial function, which possibly results from the Ser34 phosphorylations-induced mitochondrial enrichment of ATg4B and the subsequent inhibition of F1Fo-ATP synthase activity.

TL;DR: It is demonstrated that HSF1 markedly attenuated the killing effect of epirubicin (EPI) to HCC cells via enhancing the EPI-induced protective autophagy, suggesting that the "HSF1/ATG4B/protective Autophagy pathway may be a novel target for developing sensitizing strategy to H CC chemotherapy.

TL;DR: Results for the first time reveal the presence of a MIR34C-5p-ATG4B-autophagy signaling axis in THP-treated cervical cancer cells in vitro and in vivo, and the axis, at least partially, accounts for the THP nonsensitivity in cervical cancer patients.

TL;DR: It is found that miR34/ATG4B signaling axis involves in rapamycin-triggered autophagy, and this study may provide a new insight for understanding the mechanisms of ATG 4B regulation andAutophagy induction.

TL;DR: In this paper, the authors showed that CRNDE triggered autophagy via upregulating ATG4B in hepatocellular carcinoma (HCC) cells, which attenuates the sensitivity of sorafenib in HCC cells.