J
Jianhua Cheng
Researcher at University of Alabama at Birmingham
Publications - 18
Citations - 1945
Jianhua Cheng is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Fas ligand & Apoptosis. The author has an hindex of 11, co-authored 18 publications receiving 1915 citations. Previous affiliations of Jianhua Cheng include United States Department of Veterans Affairs.
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Journal ArticleDOI
Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule
Jianhua Cheng,Tong Zhou,Changdan Liu,John P. Shapiro,Matthew J. Brauer,Michael C. Kiefer,Philip J. Barr,John D. Mountz +7 more
TL;DR: Levels of soluble Fas were elevated in patients with systemic lupus erythematosus, and mice injected with soluble Fas displayed autoimmune features.
Journal ArticleDOI
Autoimmune disease. A problem of defective apoptosis.
TL;DR: Potent inducers of apoptosis including steroids, azathioprine, cyclophosphamide, and methotrexate are the most efficacious therapies for autoimmune disease currently known.
Journal ArticleDOI
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.
Tong Zhou,Jianhua Cheng,PingAr Yang,Zheng Wang,Changdan Liu,Xiao Su,Horst Bluethmann,John D. Mountz +7 more
TL;DR: In vivo analysis revealed increased activation and apoptosis of T cells associated with increased expression of Fas and Fas ligand in LN of deltaNur77-Db/HY TCR-alpha/beta double male mice, and inhibition of Nur77/Nurr1 DNA binding in T cells leads to inefficient thymicClonal deletion, but T cell tolerance is maintained by Fas-dependent clonal deletion in Ln and spleen.
Journal Article
Characterization of human Fas gene. Exon/intron organization and promoter region.
TL;DR: Using human Fas/Apo-1 cDNA as a probe, molecularly cloned and characterized the human Fas chromosomal gene and provided the first characterization of the Fas gene and insight into its regulatory region.
Journal ArticleDOI
Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation.
TL;DR: Three novel forms of Fas mRNA that are generated by alternative splicing of exons 3, 4, 6 and 7 are described and suggest that differential expression of alternatively spliced Fas mRNAs may play a role in regulation of Fas function via regulation of the production of the membrane-bound and the soluble, secreted Fas protein products.