Jianling Xie

TL;DR: A comprehensive summary of previous and recent studies relating to the complex molecular network of RAGE signalling, with a particular emphasis on RAGE transgenic mouse models is provided.

TL;DR: Progress in using inhibitors of mTOR signaling as therapeutic agents in oncology has been limited by a number of factors, including the fact that the classic mTOR inhibitor, rapamycin, inhibits only some of the effects of mTor; the existence of several feedback loops; and the crucial importance of m TOR in normal physiology.

TL;DR: It is demonstrated that mTORC1 plays an important role in skeletal development by regulating mRNA translation during preosteoblast differentiation by regulating transcripts in response to intracellular factors that control bone accrual.

TL;DR: It is shown here that the mTORC1 pathway and the oncogenic Ras/Raf/MEK/extracellular signal-regulated kinase (ERK) pathway cooperate to restrict e EF2K activity, suggesting that cancer cells may possess mechanisms to inhibit eEF2K under good growth conditions, to allow protein synthesis to proceed.

TL;DR: The number of scientific papers related to AGEs available since 1950 until 2008 is presented in the most important fields including metabolism, physiology, and pharmacology, thus as analytical methods for AGE detection and quantification and studies carried out in human body fluids.