Showing papers by "Jianping Liu published in 2022"
TL;DR: In this article , the authors discussed strategies to augment Enhanced Permeability and Retention (EPR) mediated tumor-mediated tumoral delivery in different dimensions including enhancement of vascular permeability, depletion of tumor extracellular matrix and optimization of nanoparticle design.
35 citations
TL;DR: In this article , the authors report reactive oxygen species (ROS)-responsive and size-reducible nanoassemblies, formed by multivalent host-guest interactions between β-cyclodextrins (β-CD)-anchored discoidal recombinant high-density lipoprotein (NP3ST) and hyaluronic acid-ferrocene (HA-Fc) conjugates.
10 citations
TL;DR: In this article , a theoretical model of the converse wiring method of piezoelectric inertial actuator (PIA) based on asymmetrically clamping principle is used to overcome backward motion phenomenon, which is essential for improving the stability and positioning accuracy of actuator.
6 citations
TL;DR: In this paper , micro-sized cellular platelet "ghosts" (PGs, 1.32 μm, platelet without inner granules and coagulation) were employed as carriers to ship hollow gold nanoparticles (HGNs, 58.7 nm), forming a hierarchical biosafe system to reduce normal tissue interception and enhance tumor targeting delivery of HGNs for improved photothermal therapy.
4 citations
TL;DR: In this paper , a sequential-targeting nanoplatform (HT-rHDL) was constructed to deliver LXR agonist into macrophage, which was composed of discoidal reconstituted high-density lipoprotein core for agonist encapsulation and external modifications.
4 citations
TL;DR: In this paper , a novel inertial impact piezoelectric actuator with a pair of adjustable angle vibrators is proposed, and the static analysis results obtained from the established static theoretical model indicate that the actuator has four motion states, namely stationary state, forward state without backward motion, forward states with backward motion and unstable state, which are determined by the coupling relationship between the driving voltage and the inclination angle.
4 citations
TL;DR: In this paper , a simple low cost and effective air velocity monitor (AVM) for coal mine ventilation is proposed, which uses the lock-in characteristic of vortex-induced vibration (VIV) to sense the air velocity.
Abstract: Air velocity of coal mine ventilation is an important consideration that may cause serious damage. This paper proposes a simple, low cost and effective air velocity monitor (AVM) for coal mine ventilation. The AVM uses the lock-in characteristic of vortex-induced vibration (VIV) to sense the air velocity. Amplitude of the VIV is converted into frequency signal of a vortex-induced triboelectric nanogenerator (VI-TENG) to improve the durability. Structure of the AVM are designed, and parameters of the AVM are optimized with experiments. For the upper and lower air velocity thresholds of 3.1 and 3.6 m/s, the optimized flexible beam length, slider weight, electrode space and electrode width are 42.5 mm, 0.4 g, 0.2 mm and 0.5 mm, respectively. Experiments also show that the output frequency of the VI-TENG could represent the amplitude of VIV well with the correlation coefficient of 0.93. Durability test demonstrates that the AVM generates stable output frequency in 120,000 cycles. A prototype and its controller are fabricated. Wind tunnel tests of this prototype show that it can give alarm when the gas velocity goes above the upper threshold or below the lower threshold. The proposed AVM could be a good solution for simple and effective coal mine ventilation alarm.
3 citations
TL;DR: In this paper , a TENG with a simple but durable double-float structure (DF-TENG) for wave hydrological monitoring is proposed and analyzed, where the frequency-domain parameter Ns (number of sub-signals) is utilized.
3 citations
TL;DR: The design and development of oral SHR-2042 will provide a new way to design more and more GLP-1RAs with high oral bioavailability in the future, which is over 10 times higher than that of semaglutide.
2 citations
TL;DR: Based on the superb ability of β-cyclodextrin (β-CD) to bind cholesterol crystals and promote cholesterol efflux, a simvastatin-loaded discoidal-rHDL (ST-d-RHDL) anchored with β-CD (βCD-ST-D-RDL) was constructed in this article , which specifically bound and dissolved cholesterol crystals extracellularly and intracellularly.
2 citations
TL;DR: In this paper , a bow-drill-structured TENG (BS•TENG) with a simple, cheap but effective rope-roller structure is proposed and investigated to magnify the wave motion frequency.
Abstract: Triboelectric nanogenerator (TENG) is one promising method of wave energy harvesting for marine ranching monitoring. Different from previous studies with complex structures (gears, racks, worm gears, or screw‐nut), a bow‐drill structured TENG (BS‐TENG) with a simple, cheap but effective rope‐roller structure is proposed and investigated to magnify the wave motion frequency. Inspired by the bow‐drill for carpentry, the proposed structure only simply needs a rope and roller to transfer the random wave motion into regular rotary motion with higher frequency. Results show that the structure parameters (flexible paddle number NP flexible paddle length L, electrode number NE and shaft side length D) have a great influence on the working performance of the BS‐TENG. The maximum frequency magnification ration (Rm) is 74 under the condition of 130 mm wave height (Hw); the maximum output power (P) is 450 µW. Demonstration experiments verify that the BS‐TENG is able to charge the thermo‐hygrometer and light emitting diode lights for marine ranching. Combined with the Internet of Things and 5G technologies, the BS‐TENG could be applied in the offshore sensor system for the monitoring of marine ranching information.
TL;DR: In this paper , a self-powered flow velocity sensor based on hybrid piezo-triboelectric nanogenerator (P•TENG) is proposed for monitoring the flow velocity of an urban ventilation system.
Abstract: Monitoring the flow velocity of an urban ventilation system has great significance for air circulation and air quality. In this study, a self‐powered flow velocity sensor based on hybrid piezo‐triboelectric nanogenerator (P‐TENG) is proposed. The flow velocity is detected by a triboelectric nanogenerator (TENG) working in freestanding triboelectric‐layer mode. A polyvinylidene difluoride (PVDF) fixed on the galloping beam converts the kinetic energy of the moving air into electricity. Both the TENG and PVDF are driven by the galloping vibration of a bluff body arisen from the air flow of ventilation. The structure of the P‐TENG is provided and a prototype is fabricated. The experiments indicate that the PVDF can generate 2.4 µW of energy across an external resistance of 60 MΩ. Flow velocity ranging from 4 to 10 m s−1 can be well detected by the proposed nanogenerator. Moreover, the P‐TENG is applicable to a critical environment with humidity up to 75%. Demonstration is carried out on a wind tunnel, illustrating good reliability as the frequency remains stable for the whole duration. Compared with the commercial anemometer, the error rate is under 1% after calibration. The proposed P‐TENG promises in low cost, self‐powered flow velocity monitoring in urban ventilation systems.
TL;DR: In this article , Tanshinol (TS), the bioactive component of Salvia miltiorrhiza was used as the model drug and the pharmacokinetics, pharmacodynamics and PK-PD relationship of TS was investigated in angina model rabbits.
TL;DR: In this article, the influence of release rate, dose and co-administration on pharmacokinetics (PK) and pharmacodynamics (PD) of tanshinone IIA (TA), and reveal the changes in their PK-PD relationships.
TL;DR: In this paper , the preparation of Dragon's Blood nanosuspension had a particle size of 447.0 ± 48.6 nm and was added to a composite hydrogel patch matrix for better skin application.
Abstract: Dragon's Blood is a member of the Chinese medicinal herb, having anti‐oxygen and anti‐inflammatory activity for the photoprotective effect. However, the poor water solubility of raw Dragon's Blood powder has limited its intradermal delivery process. In this study, we evaluated nanosuspensions to enhance intradermal delivery of Dragon's Blood exerting a photoprotective effect. The prepared nanosuspension was added to a composite hydrogel patch matrix for better skin application. In the present research, we used biocompatible materials hyaluronic acid and amino acid surfactants as nanosuspension stabilizers and agar/gelatin/sodium polyacrylate as hydrogel patch matrix. The prepared Dragon's Blood nanosuspension had a particle size of 447.0 ± 48.6 nm. The micro‐structures morphology and viscoelasticity characteristics by SEM and rheological testing confirmed a sufficient crosslinked hydrogel network. The skin retention amount of Dragon's Blood nanosuspension was 1.48 times of raw Dragon's Blood powder water suspension, and the skin penetration amount of Dragon's Blood nanosuspension was only about 1/3 of Dragon's Blood DMSO solution. In the UVB‐irradiated HaCaT cell phototoxicity model, Dragon's Blood nanosuspension also significantly increased cell viability by about 1 time of the model group and decreased the production of reactive oxygen species about 1/2 times of model group. In vivo safety and efficiency evaluation experiment illustrated that DB‐NS hydrogel patch processes have favorable safety and photoprotective effect with no skin irritancy and phototoxicity. Furthermore, DB‐NS and DB‐NS hydrogel patches could protect skin from UVA and UVB irritating skin reactions. Overall, our study of the combined use of biocompatible and biodegradable materials as excipients of nanosuspension and hydrogel patch could be used as an effective additive of Intradermal delivery and skin photoprotection.
TL;DR: In conclusion, combination of d-glucose in SP pellets can effectively improve the intestinal absorption and oral bioavailability of SAB.
Abstract: Abstract Salvianolic acid B (SAB) is a widely used cardioprotective agent, while its clinical application was limited by poor intestinal absorption and low oral bioavailability. In this study, SAB phospholipid (SP) complex was first prepared to improve the lipophilicity of SAB and then combined with d-glucose to further enhance intestinal absorption. Compared with free SAB, SP or the mixture of SAB and d-glucose, combination of SP and d-glucose showed higher intestinal absorption evidenced by increased effective permeation coefficient (Peff ) in the in situ single-pass intestinal perfusion (SPIP) assay. Subsequently, SP and d-glucose at mass ratio of 1:6, with the highest Peff of SAB, were chosen for the preparation of complexed pellets to improve oral absorption efficiency of SAB. As expected, the obtained pellets significantly enhanced oral bioavailability of SAB in the pharmacokinetic study characterized by increasing Cmax and AUC 0– t of SAB by 14.88-fold and 5.02-fold than free SAB, respectively. In conclusion, combination of d-glucose in SP pellets can effectively improve the intestinal absorption and oral bioavailability of SAB.
TL;DR: It is proposed that statin-loaded discoidal rHDLs should be used in combination with cholesterol-lowering statins for atherosclerotic anti-inflammatory therapy by cholesterol efflux and M2 macrophage polarization.
Abstract: Correction for 'Supramolecular copolymer modified statin-loaded discoidal rHDLs for atherosclerotic anti-inflammatory therapy by cholesterol efflux and M2 macrophage polarization' by Qiqi Zhang et al., Biomater. Sci., 2021, 9, 6153-6168, DOI: 10.1039/D1BM00610J.
TL;DR: Compared with the larger-sized discoidal rHDLs, the small-sized ST-d-rHDL possessed enhanced cellular cholesterol efflux capacity similar to drug-free one, and the effect of particle size onolesterol efflux wasn't influenced by the drug loading.
Abstract: BACKGROUND
Reverse cholesterol transportation is an essential way for high-density lipoprotein (HDL) particles to reduce the cholesterol burden of peripheral cells. Studies have shown that the particle size plays a crucial role in the cholesterol efflux capacity of HDLs, and the reconstituted HDLs (rHDLs) possess similar function to natural ones.
OBJECTIVE
The study aimed to investigate the effect of particle size on the cholesterol efflux capacity of discoidal rHDLs and whether drug loadings may have an influence on this effect.
METHODS
Different-sized simvastatin-loaded discoidal rHDLs (ST-d-rHDLs) resembling nascent HDL were prepared by optimizing key factors related to the sodium cholate of film dispersion-sodium cholate dialysis method with a controlled single factor. We characterized their physicochemical properties such as particle size, zeta potential, and morphology in vitro, and evaluated their capacity of cellular cholesterol efflux in foam cells.
RESULTS
We successfully constructed discoidal ST-d-rHDLs with different sizes (13.4 ± 1.4 nm, 36.6 ± 2.6 nm, and 68.6 ± 3.8 nm) with over 80% of encapsulation efficiency and sustained drug release. Among them, the small-sized ST-d-rHDL showed the strongest cholesterol efflux capacity and inhibitory effect on intracellular lipid deposition in foam cells. In addition, the results showed that the loaded drug didn't compromise the cellular cholesterol efflux capacity of different-sized ST-d-rHDL.
CONCLUSION
Compared with the larger-sized ST-d-rHDLs, the small-sized ST-d-rHDL possessed enhanced cellular cholesterol efflux capacity similar to drug-free one, the effect of particle size on cholesterol efflux wasn't influenced by the drug loading.
TL;DR: In this paper , a green-inspired method was employed to recycle non-split HDL from human plasma fraction IV and then it was compared with rHDL formulated by an ethanol-injection method in terms of physicochemical properties and anti-dysfunctional activities.