Jie Qin

TL;DR: A quantum yield of <1 supports the proposed catalytic cycle in which at least one photon is needed for each asymmetric C-C bond formation mediated by single electron transfer.

TL;DR: The identification and subsequent optimization of a potent BRAF inhibitor, CS292, based on an organometallic kinase inhibitor scaffold is reported on, which suggests a mechanism for regulation of BRAF by phosphorylation and BRAF(V600E) oncogene-induced activation.

TL;DR: The development of novel B-Raf(V600E) selective inhibitors via multi-step virtual screening and hierarchical hit optimization and scaffold-based analogue searching and medicinal chemistry efforts significantly improved both the inhibitor potency and oncogene selectivity.

TL;DR: The developed EM5 and FL772 inhibitors, inspired by the structure of the pan-kinase inhibitor staurosporine, to specifically inhibit S6K1 using a strategy previously used to target other kinases are demonstrated.

TL;DR: Virtual screening and chemical synthesis were employed to identify a series of N-(thiophen-2-yl) benzamide derivatives as potent BRAF(V600E) inhibitors, and structure-activity relationship studies of these derivatives revealed that compounds b40 and b47 are the two most potent BRA fusions in this series.