The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease.

Integrative analysis of 111 reference human epigenomes

https://escholarship.org/content/qt1r33f4p8/qt1r33f4p8.pdf?t=qho8bi

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission.

A COVID-19 epidemic has been spreading in China and other parts of the world since December 2019. The epidemic has brought not only the risk of death from infection but also unbearable psychological pressure. We sampled college students from Changzhi medical college by using cluster sampling. They responded to a questionnaire packet that included the 7-item Generalized Anxiety Disorder Scale (GAD-7) and those inquiring the participants' basic information. We received 7,143 responses. Results indicated that 0.9% of the respondents were experiencing severe anxiety, 2.7% moderate anxiety, and 21.3% mild anxiety. Moreover, living in urban areas (OR = 0.810, 95% CI = 0.709 - 0.925), family income stability (OR = 0.726, 95% CI = 0.645 - 0.817) and living with parents (OR = 0.752, 95% CI = 0.596 - 0.950) were protective factors against anxiety. Moreover, having relatives or acquaintances infected with COVID-19 was a risk factor for increasing the anxiety of college students (OR = 3.007, 95% CI = 2.377 - 3.804). Results of correlation analysis indicated that economic effects, and effects on daily life, as well as delays in academic activities, were positively associated with anxiety symptoms (P < .001). However, social support was negatively correlated with the level of anxiety (P < .001). It is suggested that the mental health of college students should be monitored during epidemics.

/pdf/the-psychological-impact-of-the-covid-19-epidemic-on-college-4uag8hiq2y.pdf

The psychological impact of the COVID-19 epidemic on college students in China.

Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascul...

Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.

https://www.commed.vcu.edu/Chronic_Disease/2012/cochranrvwrschbias.pdf

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

2019-nCoV epidemic: address mental health care to empower society.

Mental health considerations for children quarantined because of COVID-19.

Importance People exposed to coronavirus disease 2019 (COVID-19) and a series of imperative containment measures could be psychologically stressed, yet the burden of and factors associated with mental health symptoms remain unclear Objective To investigate the prevalence of and risk factors associated with mental health symptoms in the general population in China during the COVID-19 pandemic Design, Setting, and Participants This large-sample, cross-sectional, population-based, online survey study was conducted from February 28, 2020, to March 11, 2020 It involved all 34 province-level regions in China and included participants aged 18 years and older Data analysis was performed from March to May 2020 Main Outcomes and Measures The prevalence of symptoms of depression, anxiety, insomnia, and acute stress among the general population in China during the COVID-19 pandemic was evaluated using the Patient Health Questionnaire–9, Generalized Anxiety Disorder–7, Insomnia Severity Index, and Acute Stress Disorder Scale Logistic regression analyses were used to explore demographic and COVID-19–related risk factors Results Of 71 227 individuals who clicked on the survey link, 56 932 submitted the questionnaires, for a participation rate of 799% After excluding the invalid questionnaires, 56 679 participants (mean [SD] age, 3597 [822] years; 27 149 men [479%]) were included in the study; 39 468 respondents (696%) were aged 18 to 39 years During the COVID-19 pandemic, the rates of mental health symptoms among the survey respondents were 279% (95% CI, 275%-282%) for depression, 316% (95% CI, 312%-320%) for anxiety, 292% (95% CI, 288%-296%) for insomnia, and 244% (95% CI, 240%-247%) for acute stress Participants with confirmed or suspected COVID-19 and their family members or friends had a high risk for symptoms of depression (adjusted odds ratios [ORs], 327 [95% CI, 184-580] for patients; 153 [95% CI, 126-185] for family or friends), anxiety (adjusted ORs, 248 [95% CI, 143-431] for patients; 153 [95% CI, 127-184] for family or friends), insomnia (adjusted ORs, 306 [95% CI, 173-543] for patients; 162 [95% CI, 135-196] for family or friends), and acute stress (adjusted ORs, 350 [95% CI, 202-607] for patients; 177 [95% CI, 146-215] for family or friends) Moreover, people with occupational exposure risks and residents in Hubei province had increased odds of symptoms of depression (adjusted ORs, 196 [95% CI, 177-217] for occupational exposure; 142 [95% CI, 119-168] for Hubei residence), anxiety (adjusted ORs, 193 [95% CI, 175-213] for occupational exposure; 154 [95% CI, 130-182] for Hubei residence), insomnia (adjusted ORs, 160 [95% CI, 145-177] for occupational exposure; 120 [95% CI, 101-142] for Hubei residence), and acute stress (adjusted ORs, 198 [95% CI, 179-220] for occupational exposure; 149 [95% CI, 125-179] for Hubei residence) Both centralized quarantine (adjusted ORs, 133 [95% CI, 110-161] for depression; 146 [95% CI, 122-175] for anxiety; 163 [95% CI, 136-195] for insomnia; 146 [95% CI, 121-177] for acute stress) and home quarantine (adjusted ORs, 130 [95% CI, 125-136] for depression; 128 [95% CI, 123-134] for anxiety; 124 [95% CI, 119-130] for insomnia; 129 [95% CI, 124-135] for acute stress) were associated with the 4 negative mental health outcomes Being at work was associated with lower risks of depression (adjusted OR, 085 [95% CI, 079-091]), anxiety (adjusted OR, 092 [95% CI, 086-099]), and insomnia (adjusted OR, 087 [95% CI, 081-094]) Conclusions and Relevance The results of this survey indicate that mental health symptoms may have been common during the COVID-19 outbreak among the general population in China, especially among infected individuals, people with suspected infection, and people who might have contact with patients with COVID-19 Some measures, such as quarantine and delays in returning to work, were also associated with mental health among the public These findings identify populations at risk for mental health problems during the COVID-19 pandemic and may help in implementing mental health intervention policies in other countries and regions

/pdf/prevalence-of-and-risk-factors-associated-with-mental-health-55isyvt1pk.pdf

Prevalence of and Risk Factors Associated With Mental Health Symptoms Among the General Population in China During the Coronavirus Disease 2019 Pandemic.

Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis.

Drug use and relapse involve learned associations between drug-associated environmental cues and drug effects. Extinction procedures in the clinic can suppress conditioned responses to drug cues, but the extinguished responses typically reemerge after exposure to the drug itself (reinstatement), the drug-associated environment (renewal), or the passage of time (spontaneous recovery). We describe a memory retrieval-extinction procedure that decreases conditioned drug effects and drug seeking in rat models of relapse, and drug craving in abstinent heroin addicts. In rats, daily retrieval of drug-associated memories 10 minutes or 1 hour but not 6 hours before extinction sessions attenuated drug-induced reinstatement, spontaneous recovery, and renewal of conditioned drug effects and drug seeking. In heroin addicts, retrieval of drug-associated memories 10 minutes before extinction sessions attenuated cue-induced heroin craving 1, 30, and 180 days later. The memory retrieval-extinction procedure is a promising nonpharmacological method for decreasing drug craving and relapse during abstinence.

/pdf/a-memory-retrieval-extinction-procedure-to-prevent-drug-1u319wej8q.pdf

Jie Shi

Papers

2019-nCoV epidemic: address mental health care to empower society.

Mental health considerations for children quarantined because of COVID-19.

Prevalence of and Risk Factors Associated With Mental Health Symptoms Among the General Population in China During the Coronavirus Disease 2019 Pandemic.

Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis.

A Memory Retrieval-Extinction Procedure to Prevent Drug Craving and Relapse