J
Jim McWhir
Researcher at The Roslin Institute
Publications - 55
Citations - 11589
Jim McWhir is an academic researcher from The Roslin Institute. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 28, co-authored 55 publications receiving 11268 citations. Previous affiliations of Jim McWhir include University of Edinburgh.
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Viable offspring derived from fetal and adult mammalian cells
TL;DR: The birth of lambs from differentiated fetal and adult cells confirms that differentiation of that cell did not involve the irreversible modification of genetic material required for development to term and reinforces previous speculation that by inducing donor cells to become quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
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Sheep cloned by nuclear transfer from a cultured cell line
TL;DR: This is the first report, to the authors' knowledge, of live mammalian offspring following nuclear transfer from an established cell line, and will provide the same powerful opportunities for analysis and modification of gene function in livestock species that are available in the mouse through the use of embryonic stem cells.
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Erratum: Viable offspring derived from fetal and adult mammalian cells
TL;DR: In this Letter in the 27 February issue, a production error led to the image for part b of Fig. 1 (fetal fibroblasts) being used twice, as parts b and c.
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Viable offspring derived from fetal and adult mammalian cells.
TL;DR: Dolly was the first sheep cloned and developed from the nuclei of fully differentiated adult cells, rather than from theuclei of early embryonic cells.
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Mice with DNA repair gene ( ERCC-1 ) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning
TL;DR: Elevated p53 levels were detected in liver, brain and kidney, supporting the hypothesised role for p53 as a monitor of DNA damage in mice with defective DNA repair.