J
Jimena Rojas
Researcher at University of Valladolid
Publications - 21
Citations - 536
Jimena Rojas is an academic researcher from University of Valladolid. The author has contributed to research in topics: Proliferative vitreoretinopathy & Single-nucleotide polymorphism. The author has an hindex of 9, co-authored 21 publications receiving 431 citations. Previous affiliations of Jimena Rojas include Austral University.
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Journal ArticleDOI
Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical consequences.
J. Carlos Pastor,Jimena Rojas,Jimena Rojas,Salvador Pastor-Idoate,Salvador Pastor-Idoate,Salvatore Di Lauro,Lucia Gonzalez-Buendia,Santiago Delgado-Tirado +7 more
TL;DR: Inflammation is one of the major components of PVR, and new genetic biomarkers that have the potential to predict its development are described, including one directed towards neuroprotection, which can also be useful for preventing visual loss after any RD.
Journal ArticleDOI
A strong genetic association between the tumor necrosis factor locus and proliferative vitreoretinopathy: the retina 4 project.
Jimena Rojas,Itziar Fernández,José C. Pastor,Maria T. Garcia-Gutierrez,María R. Sanabria,Maria Brion,Rosa M. Coco,José M. Ruiz-Moreno,José García-Arumí,Javier Elizalde,Miguel Ruiz-Miguel,Jose M. Gallardo,Rosa M. Corrales,Angel Carracedo +13 more
TL;DR: A strong association found in the non-synonymous polymorphism rs2229094(T→C) of the LTA gene may indicate an important role of this polymorphism in the development of PVR, and may have significant implications regarding the genetic risk of the retinal repairing process.
Journal ArticleDOI
A genetic case-control study confirms the implication of SMAD7 and TNF locus in the development of proliferative vitreoretinopathy.
Jimena Rojas,Itziar Fernández,Jose-Carlos Pastor,Robert E MacLaren,Yashin D. Ramkissoon,Steven Harsum,DG Charteris,Jan van Meurs,Sankha Amarakoon,José M. Ruiz-Moreno,Amandio Rocha-Sousa,Maria Brion,Angel Carracedo +12 more
TL;DR: The genetic contribution to PVR and the implication of SMAD7 and TNF locus in the development of PVR are confirmed and could provide a potential new therapeutic target for PVR prophylaxis.
Journal ArticleDOI
The p53 Codon 72 Polymorphism (rs1042522) Is Associated with Proliferative Vitreoretinopathy: The Retina 4 Project
Salvador Pastor-Idoate,Salvador Pastor-Idoate,Irene Rodriguez-Hernandez,Jimena Rojas,Itziar Fernández,Maria T. Garcia-Gutierrez,José M. Ruiz-Moreno,Amandio Rocha-Sousa,Yashin D. Ramkissoon,Steven Harsum,Robert E MacLaren,Robert E MacLaren,David G. Charteris,Jan C. van Meurs,Rogelio González-Sarmiento,Jose-Carlos Pastor +15 more
TL;DR: Results indicate that the Pro variant of p53 codon 72 polymorphism is associated with a higher risk of PVR developing after a primary RD, and further studies are necessary to understand the role of this polymorphism in the development of Pvr.
Journal ArticleDOI
The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy.
Salvador Pastor-Idoate,Irene Rodriguez-Hernandez,Jimena Rojas,Itziar Fernández,Maria T. Garcia-Gutierrez,José M. Ruiz-Moreno,Amandio Rocha-Sousa,Yashin D. Ramkissoon,Steven Harsum,Robert E MacLaren,David G. Charteris,Jan C. VanMeurs,Rogelio González-Sarmiento,José C. Pastor +13 more
TL;DR: Results indicate that the G allele of rs2279744 is associated with a higher risk of developing PVR in patients undergoing a RD surgery, and further studies are necessary to understand the role of this SNP in the development of PVR.