S
Santiago Delgado-Tirado
Researcher at Harvard University
Publications - 11
Citations - 607
Santiago Delgado-Tirado is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Presenilin. The author has an hindex of 4, co-authored 8 publications receiving 368 citations. Previous affiliations of Santiago Delgado-Tirado include University of Valladolid & Massachusetts Eye and Ear Infirmary.
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Journal ArticleDOI
Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report
Joseph F. Arboleda-Velasquez,Francisco Lopera,Michael J. O'Hare,Santiago Delgado-Tirado,Claudia Marino,Natalia Chmielewska,Natalia Chmielewska,Kahira L. Saez-Torres,Dhanesh Amarnani,Aaron P. Schultz,Reisa A. Sperling,Reisa A. Sperling,David Leyton-Cifuentes,Kewei Chen,Kewei Chen,Ana Baena,David Aguillon,Silvia Rios-Romenets,Margarita Giraldo,Edmarie Guzmán-Vélez,Daniel J. Norton,Daniel J. Norton,Enmanuelle Pardilla-Delgado,Arabiye Artola,Justin S. Sanchez,Juliana Acosta-Uribe,Juliana Acosta-Uribe,Matthew A. Lalli,Kenneth S. Kosik,Matthew J. Huentelman,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Rebecca Reiman,Ji Luo,Yinghua Chen,Pradeep Thiyyagura,Yi Su,Gyungah Jun,Marcus Naymik,Xiaowu Gai,Xiaowu Gai,Moiz Bootwalla,Jianling Ji,Jianling Ji,Lishuang Shen,John B Miller,Leo A. Kim,Pierre N. Tariot,Keith A. Johnson,Keith A. Johnson,Eric M. Reiman,Yakeel T. Quiroz,Yakeel T. Quiroz +53 more
TL;DR: A unique case from the Colombian cohort of autosomal dominant Alzheimer’s disease is reported in which disease progression is substantially delayed despite unusually high amyloid plaque pathology, possibly related to a rare mutation in APOE3.
Journal ArticleDOI
Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical consequences.
J. Carlos Pastor,Jimena Rojas,Jimena Rojas,Salvador Pastor-Idoate,Salvador Pastor-Idoate,Salvatore Di Lauro,Lucia Gonzalez-Buendia,Santiago Delgado-Tirado +7 more
TL;DR: Inflammation is one of the major components of PVR, and new genetic biomarkers that have the potential to predict its development are described, including one directed towards neuroprotection, which can also be useful for preventing visual loss after any RD.
Journal ArticleDOI
Acute retinal damage after using a toxic perfluoro-octane for vitreo-retinal surgery
J. Carlos Pastor,Rosa M. Coco,Ivan Fernandez-Bueno,Maria Luz Alonso-Alonso,Jesús Medina,Aurelio Sanz-Arranz,Fernando Rull,Manuel J. Gayoso,Antonio Dueñas,Maria T. Garcia-Gutierrez,Lucia Gonzalez-Buendia,Santiago Delgado-Tirado,Emilio Abecia,Miguel Ruiz-Miguel,Miguel A Serrano,José M. Ruiz-Moreno,Girish K. Srivastava +16 more
TL;DR: In this article, a series of retinal acute toxicity cases with severe visual loss after intraocular use of a toxic perfluoro-octane (PFO) was described, and the likely causes are analyzed.
Journal ArticleDOI
TNF-α signaling regulates RUNX1 function in endothelial cells.
Hannah A.B. Whitmore,Hannah A.B. Whitmore,Dhanesh Amarnani,Dhanesh Amarnani,Michael J. O'Hare,Michael J. O'Hare,Santiago Delgado-Tirado,Santiago Delgado-Tirado,Lucia Gonzalez-Buendia,Lucia Gonzalez-Buendia,Miranda An,Miranda An,Julien Pedron,John H. Bushweller,Joseph F. Arboleda-Velasquez,Joseph F. Arboleda-Velasquez,Leo A. Kim,Leo A. Kim +17 more
TL;DR: The data suggest that the downregulation of RUNX1 in conjunction with anti‐VEGF agents may be important in future treatments for the management of diseases of pathologic ocular angiogenesis.
Journal ArticleDOI
Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators.
Michael J. O'Hare,Dhanesh Amarnani,Hannah A.B. Whitmore,Miranda An,Claudia Marino,Leslie Ramos,Santiago Delgado-Tirado,Xinyao Hu,Natalia Chmielewska,Anita Chandrahas,Antonia Fitzek,Fabian Heinrich,Stefan Steurer,Benjamin Ondruschka,Markus Glatzel,Susanne Krasemann,Diego Sepulveda-Falla,David Lagares,Julien Pedron,John H. Bushweller,Paul P. Liu,Joseph F. Arboleda-Velasquez,Leo A. Kim +22 more
TL;DR: In this paper, runt-related transcription factor 1 (RUNX1) inhibitor (Ro24-7429) was shown to improve lung fibrosis and inflammation in the bleomycin-induced PF mouse model.