J
Jin-Sung Park
Researcher at Seoul National University Hospital
Publications - 60
Citations - 1922
Jin-Sung Park is an academic researcher from Seoul National University Hospital. The author has contributed to research in topics: Medicine & Acute toxicity. The author has an hindex of 16, co-authored 45 publications receiving 1492 citations. Previous affiliations of Jin-Sung Park include Kolling Institute of Medical Research & RIKEN Brain Science Institute.
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Journal ArticleDOI
Phenotypic variability of parkin mutations in single kindred.
TL;DR: This work reports on unusual phenotypic variability within a family with mutations in parkin that is associated with autosomal recessive early‐onset Parkinson's disease.
Journal ArticleDOI
Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons
Gautam Wali,Gautam Wali,Erandhi Liyanage,Nicholas F. Blair,Nicholas F. Blair,Ratneswary Sutharsan,Ratneswary Sutharsan,Jin-Sung Park,Jin-Sung Park,Alan Mackay-Sim,Alan Mackay-Sim,Carolyn M. Sue,Carolyn M. Sue +12 more
TL;DR: Treatment of patient neurons with tubulin-binding drugs epothilone D and noscapine rescued axon peroxisome transport and protected them against axon fragmentation induced by oxidative stress, showing that SPAST patient axons are vulnerable to oxidative stress-induced degeneration as a consequence of reduced axonal transport.
Journal ArticleDOI
Loss of ATP13A2 impairs glycolytic function in Kufor-Rakeb syndrome patient-derived cell models
Jin-Sung Park,Jin-Sung Park,Brianada Koentjoro,Brianada Koentjoro,Ryan L. Davis,Ryan L. Davis,Carolyn M. Sue,Carolyn M. Sue +7 more
TL;DR: It is indicated that glycolytic dysfunction contributes to pathogenesis and pyruvate supplementation improves overall cellular bioenergetics in the KRS patient-derived cell model, highlighting a therapeutic potential.
Journal ArticleDOI
Commentary: Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease.
Journal ArticleDOI
Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants
Franca Vulinovic,Victor Krajka,Torben J. Hausrat,Philip Seibler,Daniel Alvarez-Fischer,Harutyun Madoev,Jin-Sung Park,Kishore R. Kumar,Kishore R. Kumar,Carolyn M. Sue,Katja Lohmann,Matthias Kneussel,Christine Klein,Aleksandar Rakovic +13 more
TL;DR: It is suggested that functional impairment of microtubule‐associated transport is a shared pathogenic mechanism by which the TUBB4A mutations studied here cause a spectrum of diseases.