R
Ryan L. Davis
Researcher at University of Sydney
Publications - 65
Citations - 2098
Ryan L. Davis is an academic researcher from University of Sydney. The author has contributed to research in topics: Medicine & Mitochondrial disease. The author has an hindex of 20, co-authored 56 publications receiving 1371 citations. Previous affiliations of Ryan L. Davis include Garvan Institute of Medical Research & Kolling Institute of Medical Research.
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Journal ArticleDOI
Mitochondrial Dysfunction in Parkinson's Disease: New Mechanistic Insights and Therapeutic Perspectives.
TL;DR: Increasing evidence supports the critical role for mitochondrial dysfunction in the development of sporadic PD, while the involvement of familial PD-related genes in the regulation of mitochondrial biology has been expanded by the discovery of new mitochondria-associated disease loci and the identification of their novel functions.
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Next-Generation Sequencing and Emerging Technologies.
Kishore R. Kumar,Kishore R. Kumar,Kishore R. Kumar,Mark J. Cowley,Mark J. Cowley,Ryan L. Davis,Ryan L. Davis +6 more
TL;DR: This review provides an updated overview of next-generation sequencing (NGS) and emerging methodologies and describes short-read sequencing approaches, such as sequencing by synthesis, ion semiconductor sequencing, and nanoball sequencing.
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Parkinson's disease and the gastrointestinal microbiome
Michal Lubomski,Ai Huey Tan,Shen-Yang Lim,Andrew J. Holmes,Ryan L. Davis,Carolyn M. Sue,Carolyn M. Sue +6 more
TL;DR: Evidence linking GM changes with PD is reviewed, highlighting mechanisms supportive of pathological α-synuclein spread and intestinal inflammation in PD and roles of GM modulating therapies including probiotics and faecal microbiota transplantation are discussed.
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Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy.
Roula Ghaoui,Johanna Palmio,Janice Brewer,Monkol Lek,Merrilee Needham,Anni Evilä,Peter Hackman,Per Harald Jonson,Sini Penttilä,Anna Vihola,Sanna Huovinen,Mikaela Lindfors,Ryan L. Davis,Leigh B. Waddell,Simran Kaur,Con Yiannikas,Kathryn N. North,Nigel F. Clarke,Daniel G. MacArthur,Carolyn M. Sue,Bjarne Udd +20 more
TL;DR: Patients can develop a myopathy with histologic features of myofibrillar myopathic with aggregates and rimmed vacuoles, similar to the pathology in myopathies due to gene defects in other compounds of the CASA complex such as BAG3 and DNAJB6 after developing the early neurogenic effects.
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Expression of the long form of the prolactin receptor in magnocellular oxytocin neurons is associated with specific prolactin regulation of oxytocin neurons.
TL;DR: Together, these data provide strong evidence that prolactin directly and specifically regulates activity of oxytocin neurons.