Jin Zhong

TL;DR: It is demonstrated that IL‐28 (IFN‐λ 2/3) IFN production, similar to type I IFN, represents a primary and direct host response to HCV genomic RNA transfection and it is shown that HCV infection can inhibit IL‐ 28 expression, and that the viral NS3/4A protease activity was responsible for this inhibitory effect.

TL;DR: The data indicated that apoE expression level in uninfected cells is important for high permissiveness to HCV infection and suggested that exchangeable apolipoproteins reach a natural equilibrium between HCV LVPs and lipoprotein particles, which provides a new perspective to the understanding of the heterogeneity of HCVLVPs in composition.

TL;DR: Nitazoxanides and its bioactive metabolite, tizoxanide, have anti-ZIKV potential in vitro, and it is identified that they exerts antiviral effect possibly by targeting the viral postattachment step.

TL;DR: This work designed and produced a fusion protein (sE2-Ferritin) comprising sE2 and a Ferritin unit in Drosophila S2 cells, which self-assembled into a nanoparticle with sE 2 displayed on the surface, providing a new possibility to control HCV.

TL;DR: It is demonstrated that POM-12 had no effect on the vesicular stomatitis virus infection while had weak inhibitory activity against the influenza virus infection.