J
Jin Zhong
Researcher at Chinese Academy of Sciences
Publications - 172
Citations - 7453
Jin Zhong is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 34, co-authored 149 publications receiving 6352 citations. Previous affiliations of Jin Zhong include Scripps Research Institute & ShanghaiTech University.
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Journal ArticleDOI
An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3.
Ling Xu,Ling Xu,Dandan Yu,Dandan Yu,Li Peng,Yong Wu,Yu Fan,Tianle Gu,Tianle Gu,Yu-Lin Yao,Yu-Lin Yao,Jin Zhong,Xinwen Chen,Yong-Gang Yao +13 more
TL;DR: Tupaia STING has two alternative splicing isoforms, tSTing-FL and tSTING-mini, which played a key role in the HSV-1–triggered type I IFN signaling pathway, whereas tSTings-mini was critical for RNA virus-induced antiviral signaling transduction.
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Immunization With a Subunit Hepatitis C Virus Vaccine Elicits Pan-Genotypic Neutralizing Antibodies and Intrahepatic T-Cell Responses in Nonhuman Primates.
Dapeng Li,Xuesong Wang,Markus von Schaewen,Wanyin Tao,Yunfang Zhang,Brigitte Heller,Gabriela Hrebikova,Qiang Deng,Qiang Sun,Alexander Ploss,Jin Zhong,Zhong Huang +11 more
TL;DR: SE2 is a promising HCV vaccine candidate that warrants further preclinical and clinical development and a significant correlation between the sE2-specific immunoglobulin G titers and neutralization spectrum was observed, highlighting the essential role of sE 2 immunogenicity on achieving broad NAbs.
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The N-terminal helix α0 of hepatitis C virus NS3 protein dictates the subcellular localization and stability of NS3/NS4A complex
TL;DR: It is demonstrated that the amphipathic helix α(0) of NS3 protein determines the proper membrane association of NS2, and this subcellular localization dictates the functional role ofNS3 in the HCV life cycle.
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Construction and characterization of infectious hepatitis C virus chimera containing structural proteins directly from genotype 1b clinical isolates
TL;DR: Developing 1b/JFH-1 inter-genotypic recombinants containing the structural genes (Core, E1, E2, p7 and the 1stTMD of NS2 directly from GT1b clinical isolates will be important for studies of isolate-specific neutralization and useful in evaluating antiviral therapies.
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Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance.
Chao Zhang,Rui Hua,Yuanyuan Cui,Shasha Wang,Hongqing Yan,Dongmei Li,Yonghong Zhang,Zhengkun Tu,Pei Hao,Xinyue Chen,Jin Zhong,Junqi Niu,Xia Jin +12 more
TL;DR: Results indicate that T cell responses may be a correlate of protection, and therefore, effective preventative vaccines should elicit a robust T cell response.