J
Jinfang Ma
Researcher at Johns Hopkins University
Publications - 7
Citations - 1126
Jinfang Ma is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cancer cell & Cancer. The author has an hindex of 7, co-authored 7 publications receiving 915 citations.
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Journal ArticleDOI
Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model
Thomas E. Sussan,Sachin Gajghate,Rajesh K. Thimmulappa,Jinfang Ma,Jung Hyun Kim,Kuladeep Sudini,Nicola Consolini,Stephania A. Cormier,Slawo Lomnicki,Farhana Hasan,Andrew Pekosz,Shyam Biswal +11 more
TL;DR: It is demonstrated that E-cig exposure elicits impaired pulmonary anti-microbial defenses and must be rigorously tested in users for their effects on immune response and susceptibility to bacterial and viral infections.
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Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
Anju Singh,Sreedhar Venkannagari,Kyu H. Oh,Ya Qin Zhang,Jason M. Rohde,Li Liu,Sridhar Nimmagadda,Kuladeep Sudini,Kyle R. Brimacombe,Sachin Gajghate,Jinfang Ma,Amy Wang,Xin Xu,Sampada A. Shahane,Menghang Xia,Juhyung Woo,George A. Mensah,Zhibin Wang,Marc Ferrer,Edward Gabrielson,Zhuyin Li,Fraydoon Rastinejad,Min Shen,Matthew B. Boxer,Shyam Biswal +24 more
TL;DR: It is concluded that targeting NRF2 may represent a promising strategy for the treatment of advanced NSCLC because of its high specificity and selectivity and its ability to bind to and inhibit its downstream target gene expression.
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Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype
TL;DR: Nrf2-mediated regulation of ABCG2 expression maintains the SP fraction and confers chemoresistance, and its role in the multidrug resistance phenotype is examined.
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Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients
Deepti Malhotra,Rajesh K. Thimmulappa,Nicolas Mercado,Kazuhiro Ito,Ponvijay Kombairaju,Sarvesh Kumar,Jinfang Ma,David Feller-Kopman,Robert A. Wise,Peter J. Barnes,Shyam Biswal +10 more
TL;DR: It is shown that in alveolar macrophages from patients with COPD, S-nitrosylation of HDAC2 is increased and that this abolishes its GR-transrepression activity and promotes corticosteroid insensitivity, and concludes that NRF2 is a novel drug target for reversing cortiosteroid resistance in COPD and other corticosticosteroid-resistant inflammatory diseases.
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Plasma miRNA as Biomarkers for Assessment of Total-Body Radiation Exposure Dosimetry
TL;DR: Plasma-based biomarkers can be used to assess radiation exposure after mass-casualty incidents, and it may provide a valuable tool in developing and implementing effective countermeasures.