Institution
MCPHS University
Education•Boston, Massachusetts, United States•
About: MCPHS University is a education organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Pharmacy & Health care. The organization has 1408 authors who have published 2136 publications receiving 42950 citations. The organization is also known as: MCPHS University.
Topics: Pharmacy, Health care, Population, Clinical pharmacy, Pharmacy practice
Papers published on a yearly basis
Papers
More filters
•
01 Mar 2012TL;DR: This latest edition offers an unparalleled presentation of drug discovery and pharmacodynamic agents, integrating principles of medicinal chemistry with pharmacology, pharmacokinetics, and clinical pharmacy.
Abstract: Acclaimed by students and instructors alike, "Foye's Principles of Medicinal Chemistry "is now in its Seventh Edition, featuring updated chapters plus new material that meets the needs of today's medicinal chemistry courses. This latest edition offers an unparalleled presentation of drug discovery and pharmacodynamic agents, integrating principles of medicinal chemistry with pharmacology, pharmacokinetics, and clinical pharmacy. All the chapters have been written by an international team of respected researchers and academicians. Careful editing ensures thoroughness, a consistent style and format, and easy navigation throughout the text.
1,314 citations
••
842 citations
••
TL;DR: A microfluidic device lined by living human kidney epithelial cells exposed to fluidic flow that mimics key functions of the human kidney proximal tubule is described, suggesting that it might serve as a useful tool for evaluating human-relevant renal toxicity in preclinical safety studies.
Abstract: Kidney toxicity is one of the most frequent adverse events reported during drug development. The lack of accurate predictive cell culture models and the unreliability of animal studies have created a need for better approaches to recapitulate kidney function in vitro. Here, we describe a microfluidic device lined by living human kidney epithelial cells exposed to fluidic flow that mimics key functions of the human kidney proximal tubule. Primary kidney epithelial cells isolated from human proximal tubule are cultured on the upper surface of an extracellular matrix-coated, porous, polyester membrane that splits the main channel of the device into two adjacent channels, thereby creating an apical ‘luminal’ channel and a basal ‘interstitial’ space. Exposure of the epithelial monolayer to an apical fluid shear stress (0.2 dyne cm−2) that mimics that found in living kidney tubules results in enhanced epithelial cell polarization and primary cilia formation compared to traditional Transwell culture systems. The cells also exhibited significantly greater albumin transport, glucose reabsorption, and brush border alkaline phosphatase activity. Importantly, cisplatin toxicity and Pgp efflux transporter activity measured on-chip more closely mimic the in vivo responses than results obtained with cells maintained under conventional culture conditions. While past studies have analyzed kidney tubular cells cultured under flow conditions in vitro, this is the first report of a toxicity study using primary human kidney proximal tubular epithelial cells in a microfluidic ‘organ-on-a-chip’ microdevice. The in vivo-like pathophysiology observed in this system suggests that it might serve as a useful tool for evaluating human-relevant renal toxicity in preclinical safety studies.
649 citations
••
TL;DR: Acute, subacute/subchronic, and chronic toxicity profiles have been established to determine that triclosan is neither an acute oral toxicant nor that it acts as a carcinogen, mutagen, or teratogen.
498 citations
••
TL;DR: It was found that females and those who were younger, more educated, and healthier were significantly more patient-centered and years in practice was related to satisfaction and orientation in a non-linear fashion.
435 citations
Authors
Showing all 1417 results
Name | H-index | Papers | Citations |
---|---|---|---|
David W. Bates | 159 | 1239 | 116698 |
Vladimir P. Torchilin | 109 | 627 | 58977 |
David A. Williams | 106 | 633 | 42058 |
Howard Hu | 81 | 405 | 36025 |
Ted J. Kaptchuk | 80 | 324 | 25473 |
Richard L. Kravitz | 78 | 357 | 24412 |
Bruce R. Bistrian | 77 | 590 | 25634 |
George L. Blackburn | 77 | 418 | 20660 |
Robert O. Wright | 71 | 423 | 18690 |
Lawrence J. Lesko | 63 | 243 | 12364 |
Robert N. Jamison | 59 | 198 | 10406 |
David H. Thom | 56 | 143 | 11343 |
Abhishek Sharma | 52 | 426 | 9715 |
Peter M. Wayne | 52 | 174 | 7727 |
Lemont B. Kier | 49 | 235 | 11699 |