Jing Du

TL;DR: A critical role is reported for hyperglycemia-induced repression of miR-24 in VWF-induced pathology, which represents a novel therapeutic target to prevent adverse thrombotic events in patients with diabetes mellitus.

TL;DR: It is reported that platelet mitophagy induction serves as a platelet protective mechanism that responds to oxidative stress through JNK activation, and by removing damaged mitochondria (mitophagy), phosphorylated p53 is reduced, preventing progression to apoptosis, and preserving platelet function.

TL;DR: It is demonstrated that platelet apoptosis and hyperactivation are 2 distinct states that depend on the severity of the hyperglycemia and mitochondrial damage, and Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53.

TL;DR: Spectroscopic methods imply that the His tag has the ability to stabilize heme binding as well as alter heme ligand coordination of Rv0203 by providing an unnatural histidine ligand.

TL;DR: The use of magnetic circular dichroism and electronic absorption spectroscopy is reviewed to characterize nitrogen-, oxygen-, and sulfur-donor-ligated H93G Mb adducts with an emphasis on species not easily prepared by other heme model system approaches and those that serve as spectroscopic models for native heme proteins.