J
Jing Guo
Researcher at Saga University
Publications - 3
Citations - 32
Jing Guo is an academic researcher from Saga University. The author has contributed to research in topics: Gene knockdown & Programmed cell death. The author has an hindex of 3, co-authored 3 publications receiving 25 citations.
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Journal ArticleDOI
PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression.
Jing Guo,Iwata Ozaki,Jinghe Xia,Takuya Kuwashiro,Motoyasu Kojima,Hirokazu Takahashi,Kenji Ashida,Keizo Anzai,Sachiko Matsuhashi +8 more
TL;DR: In this article, the authors examined the cell cycle regulators whose activation is affected by PDCD4 knockdown to investigate the contribution of PD-CD4 to cell cycle regulation in three types of hepatoma cells: HepG2, Huh7, and Hep3B.
PDCD4 knockdown induces senescence in hepatoma cells by up-regulating p21 expression
Jing Guo,Iwata Ozaki,Jinghe Xia,Manirujjaman,Takuya Kuwashiro,Motoyasu Kojima,Hirokazu Takahashi,Yuichro Eguchi,Keizo Anzai,Sachiko Matsuhashi +9 more
TL;DR: It is found that apoptosis was induced in a p53-dependent manner in PDCD4 knockdown HepG2 cells (p53+), although the mechanism of cell death was different and may be a promising therapeutic target for the treatment of hepatocellular carcinoma.
Journal ArticleDOI
Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy.
M. Manirujjaman,Iwata Ozaki,Yuzo Murata,Jing Guo,Jinghe Xia,Kenichi Nishioka,Rasheda Perveen,Hirokazu Takahashi,Keizo Anzai,Sachiko Matsuhashi +9 more
TL;DR: It is concluded that after phosphorylation in the degron and ubiquitination, PDCD4 is degraded by both the proteasome and autophagy systems.