Multicomponent reactions in unconventional solvents: state of the art

Metal-Free Multicomponent Syntheses of Pyridines

The efficiency of a chemical synthesis can be nowadays measured, not only by parameters like selectivity and overall yield, but also by its raw material, time, human resources and energy requirements, as well as the toxicity and hazard of the chemicals and the protocols involved. The development of multicomponent reactions (MCRs) in the presence of task-specific ionic liquids (ILs), used not only as environmentally benign reaction media, but also as catalysts, is a new approach that meet with the requirements of sustainable chemistry. The aim of this tutorial review is to highlight the synergistic effect of the combined use of MCRs and ILs for the development of new eco-compatible methodologies for heterocyclic chemistry.

/pdf/multicomponent-reactions-and-ionic-liquids-a-perfect-synergy-8npxrjmgdf.pdf

Multicomponent reactions and ionic liquids: a perfect synergy for eco-compatible heterocyclic synthesis

Centro de Quı́mica-Fı́sica Molecular (CQFM) and Institute of Nanosciences and Nanotechnology (IN), Departamento de Engenharia Quı́mica e Biológica, Instituto Superior Técnico, 1049-001 Lisboa, Portugal, REQUIMTE, Departamento de Quı́mica, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Quinta da Torre, 2829-516 Caparica, Portugal, and iMed.UL, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

More sustainable approaches for the synthesis of N-based heterocycles.

An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile (cyanoacetic ester) and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, low cost, and convenient operation

Efficient one-pot synthesis of spirooxindole derivatives catalyzed by L-proline in aqueous medium.

An Efficient synthesis of pyrimido[4,5-b]quinoline and indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine derivatives via multicomponent reactions in ionic liquid

An efficient synthesis of polyhydroacridine derivatives by the three-component reaction of aldehydes, amines and dimedone in ionic liquid

One-pot synthesis of pyrido[2,3-d]pyrimidines via efficient three-component reaction in aqueous media

A series of indeno[2',1':5,6]pyrido[2,3-d]pyrazoles was synthesized by the three-component reaction of aldehyde, 5-amino-3-methyl-1-phenylpyrazole and 1,3-indenedione in the presence of SDS in aqueous media. The structures were characterized by IR, 1 H NMR, high resolution mass spectra and were further confirmed by X-ray diffraction analysis.

http://proj3.sinica.edu.tw/~chem/servxx6/files/paper_10964_1246595803.pdf

Three‐Component One‐Pot Synthesis of Indeno[2′,1′:5,6]Pyrido[2,3‐d]Pyrazole Derivatives in Aqueous Media

A series of pyrazolo[3,4-b]pyridines was synthesized by the reaction of 5-aminopyrazole with benzylidenemalononitrile in aqueous media. The structures were characterized by IR, 1H NMR, and elemental analysis and were further confirmed by X-ray diffraction analysis.

Jing-Wen Shi

Papers

An Efficient synthesis of pyrimido[4,5-b]quinoline and indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine derivatives via multicomponent reactions in ionic liquid

An efficient synthesis of polyhydroacridine derivatives by the three-component reaction of aldehydes, amines and dimedone in ionic liquid

One-pot synthesis of pyrido[2,3-d]pyrimidines via efficient three-component reaction in aqueous media

Three‐Component One‐Pot Synthesis of Indeno[2′,1′:5,6]Pyrido[2,3‐d]Pyrazole Derivatives in Aqueous Media

An Efficient Synthesis of Pyrazolo[3,4‐b]Pyridine Derivatives in Aqueous Media