Jingjing Cheng

TL;DR: The results first reveal the presynaptic mGluR5-PIP2 pathway whereby oligomeric Aβ induces early synaptic deficits in AD and rescues synaptic and spatial learning and memory deficits in APP/PS1 mice.

TL;DR: This work reveals that activation of the aPVT-NAc pathway in mice generates a motivation to consume food in a novel environment.

TL;DR: The reduced exploratory behaviors under approach-avoidance conflict were not due to a high anxiety level or an enhanced fear response in the TLR4−/− mice, as these mice showed normal anxiety and fear responses in the open field and passive avoidance tests, respectively.

TL;DR: High-fat diet is provided to dams during lactation and to pups after weaning and a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity suggests good construction validity of obesity and precocious puberty.

TL;DR: It is reported that high-fat diet consumption impedes threat-cue-induced suppression of sucrose-seeking in mice and compulsive food-seeking was due to enhanced cue-triggered neuronal activity in the anterior paraventricular thalamus resulting from HFD-induced microglia activation.