Jingman Ni

TL;DR: The straightforward process, catalyzed by a bifunctional chiral squaramide catalyst, serves as a powerful tool for the enantioselective construction of potentially biological bioxindoles with four contiguous chiral centers, of which two are spiro all-carbon quaternary centers on a single cyclopentane ring.

TL;DR: The results from the outer/inner membrane permeabilization and cytoplasmic membrane depolarization assays and flow cytometry and scanning electron microscopy analyses demonstrated that the new peptides exert antimicrobial effects by typical non-receptor-mediated membrane mechanisms, as well as intracellular targets characterized by gel retardation and reactive oxygen species (ROS) generation assays.

TL;DR: HG is beneficial for regulating the stability of blood lipids, has atheroprotective characteristics and may prevent nonalcoholic fatty liver disease (NAFLD), providing more than just a theoretical basis for drug research of cardiovascular disease (CVD) treatment.

TL;DR: The conjugation of fatty acids at the N-terminus of peptides and dimerization are promising strategies for obtaining potent antimicrobial agents.

TL;DR: A series of halogenated derivatives of the antimicrobial peptide Jelleine‐I were designed and synthesized and showed that the in vitro antimicrobial activity, antibiofilm activity and in vivo antimicrobial efficacy were enhanced 1–8‐fold after halogenation.