J
Jingyuan Deng
Researcher at Fred Hutchinson Cancer Research Center
Publications - 2
Citations - 2326
Jingyuan Deng is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Gene expression profiling. The author has an hindex of 2, co-authored 2 publications receiving 1127 citations.
Papers
More filters
Journal ArticleDOI
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
Greg Finak,Andrew McDavid,Masanao Yajima,Jingyuan Deng,Vivian H. Gersuk,Alex K. Shalek,Chloe K. Slichter,Hannah W. Miller,M. Juliana McElrath,Martin Prlic,Peter S. Linsley,Raphael Gottardo +11 more
TL;DR: This work argues that the cellular detection rate, the fraction of genes expressed in a cell, should be adjusted for as a source of nuisance variation and provides gene set enrichment analysis tailored to single-cell data.
Posted ContentDOI
MAST: A flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA-seq data
Greg Finak,Andrew McDavid,Masanao Yajima,Jingyuan Deng,Vivian H. Gersuk,Alex K. Shalek,Chloe K. Slichter,Hannah W. Miller,M. Juliana McElrath,Martin Prlic,Peter S. Linsley,Raphael Gottardo +11 more
TL;DR: A new methodology to analyze single-cell transcriptomic data is presented that models this bimodality within a coherent generalized linear modeling framework, and the cellular detection rate, the fraction of genes turned on in a cell, is introduced.