Vivian H. Gersuk

TL;DR: This work argues that the cellular detection rate, the fraction of genes expressed in a cell, should be adjusted for as a source of nuisance variation and provides gene set enrichment analysis tailored to single-cell data.

TL;DR: Human TR cells were examined and, in results similar to those of studies done in mice, expression of FoxP3 was found exclusively in CD4+CD25+ T cells and correlated with the suppressive activity of these cells, raising the possibility that a failure to generate peripheral TR cells properly may contribute to autoimmune disease.

TL;DR: In this paper, a negative selection mechanism was used to eliminate potentially autoreactive clones in the thymus of T cells through elimination of potentially auto-active clones through negative selection.

TL;DR: A new methodology to analyze single-cell transcriptomic data is presented that models this bimodality within a coherent generalized linear modeling framework, and the cellular detection rate, the fraction of genes turned on in a cell, is introduced.

TL;DR: The aim of this study was to improve characterization of the blood IFN signature in adult SLE patients.