J
Jinjiang Fan
Researcher at McGill University Health Centre
Publications - 63
Citations - 3582
Jinjiang Fan is an academic researcher from McGill University Health Centre. The author has contributed to research in topics: Translocator protein & Mitochondrion. The author has an hindex of 30, co-authored 63 publications receiving 3138 citations. Previous affiliations of Jinjiang Fan include Wadsworth Center & McGill University.
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Journal ArticleDOI
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
Rainer Rupprecht,Vassilios Papadopoulos,Gerhard Rammes,Thomas C. Baghai,Jinjiang Fan,Nagaraju Akula,Ghislaine Groyer,David H. Adams,Michael Schumacher +8 more
TL;DR: The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial membrane of steroid-synthesizing cells, including those in the central and peripheral nervous system, which is a prerequisite for steroid synthesis.
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Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states.
TL;DR: The focus of this review is on the intracellular pathways and protein-protein interactions involved in cholesterol transport and steroid biosynthesis and the roles and interactions of these proteins in endocrine pathologies and neurological diseases where steroid synthesis plays a critical role.
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Identification of a Dynamic Mitochondrial Protein Complex Driving Cholesterol Import, Trafficking, and Metabolism to Steroid Hormones
Malena B. Rone,Andrew Midzak,Leeyah Issop,Georges Rammouz,Sathvika Jagannathan,Jinjiang Fan,Xiaoying Ye,Josip Blonder,Timothy D. Veenstra,Vassilios Papadopoulos +9 more
TL;DR: A bioactive, multimeric protein complex spanning the OMM and IMM unit that is responsible for the hormone-induced import, segregation, targeting, and metabolism of cholesterol is identified.
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Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): An emerging signaling molecule
TL;DR: New findings about ACBD3 may help understand this newly characterized signaling molecule and stimulate further research into its role in molecular endocrinology, neurology, and stem cell biology.
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Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation
Jinjiang Fan,Jinjiang Fan,Enrico Campioli,Enrico Campioli,Andrew Midzak,Andrew Midzak,Martine Culty,Martine Culty,Vassilios Papadopoulos +8 more
TL;DR: Translocator protein (TSPO), a key member of the mitochondrial cholesterol transport complex in steroidogenic tissues, was found necessary for preimplantation embryo development and ACTH-stimulated steroid biosynthesis.