Jiří Raboch

TL;DR: Current biological hypotheses of BD are summarized, including related pathophysiological processes and key biomarkers, which have been associated with changes in genetics, systems of neurotransmitter and neurotrophic factors, neuroinflammation, autoimmunity, cytokines, stress axis activity, chronobiology, oxidative stress, and mitochondrial dysfunctions.

TL;DR: It is demonstrated that AD is accompanied by increased CREB activity in lymphocytes and a decreased concentration of BDNF in platelet-rich plasma, which appears to correlate with moderate to severe stages of dementia in AD.

TL;DR: The EUNOMIA project, an international study funded by the European Commission, aims to assess the clinical practice of coercive treatment measures and their outcomes and its naturalistic and epidemiological design is being implemented at 13 centres in 12 countries.

TL;DR: The European Commission has funded the EUNOMIA study in 12 European countries in order to develop European recommendations for good clinical practice in involuntary hospital admissions as discussed by the authors, which have been developed with the direct and active involvement of national leaders and key professionals.

TL;DR: Results indicate that changes in respiratory rate in intact platelets can be used as biological marker of depressive disorder and the hypothesis that decreased mitochondrial respiratory rate participate in pathophysiology of depression was supported.