J
Jiri Vachtenheim
Researcher at First Faculty of Medicine, Charles University in Prague
Publications - 54
Citations - 1182
Jiri Vachtenheim is an academic researcher from First Faculty of Medicine, Charles University in Prague. The author has contributed to research in topics: Microphthalmia-associated transcription factor & Melanoma. The author has an hindex of 16, co-authored 44 publications receiving 1006 citations. Previous affiliations of Jiri Vachtenheim include Charles University in Prague & Laboratory of Molecular Biology.
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Journal ArticleDOI
"Transcription physiology" of pigment formation in melanocytes: central role of MITF.
Jiri Vachtenheim,Jan Borovanský +1 more
TL;DR: Transcription physiology of pigment formation in melanocytes: central role of (MITF) is studied.
Journal Article
The Microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription.
TL;DR: The results obtained show that the adenovirus E1A 13S, but not the 12S, product can transform the highly pigmented and TPA-dependent melanocyte cell line melan-a, and that the mi gene appears to play a crucial role in melanocyte-specific gene expression.
Journal ArticleDOI
TRP-1 expression correlates with eumelanogenesis in human pigment cells in culture.
V. Del Marmol,Shosuke Ito,Ian J. Jackson,Jiri Vachtenheim,P. Berr,Ghanem Elias Ghanem,Renato Morandini,Kazumasa Wakamatsu,Georges Huez +8 more
TL;DR: Investigation of the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosInase‐related protein‐1 (TRP‐1), the activity of tyros inase and the presence of melanin suggests a role for TRP‐ 1 in the eumelanin synthesis pathway.
Journal ArticleDOI
Transcriptional Repression of the Microphthalmia Gene in Melanoma Cells Correlates with the Unresponsiveness of Target Genes to Ectopic Microphthalmia-Associated Transcription Factor
TL;DR: It is suggested that a specific nuclear context is required for the transcriptional activation of the melanocyte markers by the microphthalmia transcription factor in malignant melanocytes and this specificity is lost concomitantly with the transcriptionAL repression of microphthalia transcription factor.
Journal Article
Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas.
Jiri Vachtenheim,H Novotná +1 more
TL;DR: The results indicate that the MITF-M isoform is the major type of MITF mRNA present in human melanoma cell lines and show that the expression of the isoformMITF-A and the MSG1 is not restricted to malignant melanocytes and occurs in a wide range of tumor cell lines.