G
Ghanem Elias Ghanem
Researcher at Université libre de Bruxelles
Publications - 190
Citations - 6404
Ghanem Elias Ghanem is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Melanoma & Receptor. The author has an hindex of 41, co-authored 180 publications receiving 5513 citations. Previous affiliations of Ghanem Elias Ghanem include Institut Jules Bordet & Free University of Brussels.
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Journal ArticleDOI
Hypopigmenting agents: an updated review on biological, chemical and clinical aspects
TL;DR: An overview of agents causing hypopigmentation in human skin is presented and it is suggested that Mammalian skin or at least keratinocytes/melanocytes co-cultures should be preferred rather than pure melanocyte cultures or soluble tyrosinase.
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Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state
Annelien Verfaillie,Hana Imrichova,Zeynep Kalender Atak,Michael Dewaele,Florian Rambow,Gert Hulselmans,Valerie Christiaens,Dmitry Svetlichnyy,Flavie Luciani,Laura Van den Mooter,Sofie Claerhout,Mark Fiers,Fabrice Journe,Ghanem Elias Ghanem,Carl Herrmann,Georg Halder,Jean-Christophe Marine,Stein Aerts +17 more
TL;DR: Using regulatory landscapes and in silico analysis, it is shown that transcriptional reprogramming underlies the distinct cellular states present in melanoma and reveals an essential role for the TEADs, linking it to clinically relevant mechanisms such as invasion and resistance.
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Melanins and melanogenesis: from pigment cells to human health and technological applications.
Marco d'Ischia,Kazumasa Wakamatsu,Fabio Cicoira,Eduardo Di Mauro,José C. García-Borrón,Stephane Commo,Ismael Galván,Ghanem Elias Ghanem,Koike Kenzo,Paul Meredith,Alessandro Pezzella,Clara Santato,Tadeusz Sarna,John D. Simon,Luigi Zecca,Fabio A. Zucca,Alessandra Napolitano,Shosuke Ito +17 more
TL;DR: An interdisciplinary perspective of melanin pigments and related pathway is provided with a view to showing how it is possible to translate current knowledge about physical and chemical properties and control mechanisms into new bioinspired solutions for biomedical, dermocosmetic, and technological applications.
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MDM4 is a key therapeutic target in cutaneous melanoma
Agnieszka Gembarska,Agnieszka Gembarska,Flavie Luciani,Flavie Luciani,Clare G Fedele,Clare G Fedele,Elisabeth A. Russell,Michael Dewaele,Michael Dewaele,Stephanie Villar,Aleksandra Zwolinska,Aleksandra Zwolinska,Sue Haupt,Sue Haupt,Job de Lange,Dana Yip,James S. Goydos,Jody J. Haigh,Ygal Haupt,Ygal Haupt,Ygal Haupt,Lionel Larue,Aart G. Jochemsen,Hubing Shi,Gatien Moriceau,Roger S. Lo,Ghanem Elias Ghanem,Mark Shackleton,Mark Shackleton,Federico Bernal,Jean-Christophe Marine,Jean-Christophe Marine +31 more
TL;DR: It is shown that Mdm4 p53 binding protein homolog (MDM4), a negative regulator of p53, is upregulated in a substantial proportion (∼65%) of stage I–IV human melanomas and that melanocyte-specific MDM4 overexpression enhanced tumorigenesis in a mouse model of melanoma induced by the oncogene Nras.
Journal ArticleDOI
Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression.
Geertrui Denecker,Niels Vandamme,Özden Akay,Dana Koludrovic,Joachim Taminau,Kelly Lemeire,Alexander Gheldof,B De Craene,M. Van Gele,Lieve Brochez,Girish Mallya Udupi,Mairin Rafferty,Balázs Bálint,William M. Gallagher,Ghanem Elias Ghanem,Danny Huylebroeck,Danny Huylebroeck,Jody J. Haigh,J. J. Van Den Oord,Lionel Larue,Irwin Davidson,J-C Marine,Geert Berx +22 more
TL;DR: A transcriptional signaling network in which the EMT transcription factor ZEB2 regulates MITF levels to control melanocyte differentiation is identified and is relevant for human melanomagenesis as loss of Zeb2 expression is associated with reduced patient survival.