J
Jiyong Zhao
Researcher at Harvard University
Publications - 24
Citations - 1603
Jiyong Zhao is an academic researcher from Harvard University. The author has contributed to research in topics: Cell cycle & DNA replication. The author has an hindex of 14, co-authored 24 publications receiving 1515 citations. Previous affiliations of Jiyong Zhao include University of Rochester Medical Center & University of Rochester.
Papers
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Journal ArticleDOI
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.
Jiyong Zhao,Jiyong Zhao,Brian K. Kennedy,Brandon D. Lawrence,David A. Barbie,A. Gregory Matera,Jonathan A. Fletcher,Ed Harlow +7 more
TL;DR: It is demonstrated that NPAT activates histone gene transcription and that this activation is dependent on the promoter elements (SSCSs) previously proposed to mediate cell cycle-dependent transcription.
Journal ArticleDOI
Expression of NPAT, a novel substrate of cyclin E–CDK2, promotes S-phase entry
TL;DR: It is shown that NPAT associates with cyclin E-CDK2 in vivo and can be phosphorylated by this CDK and plays a role in S-phase entry.
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Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A
Mary Pulvino,Yue Liang,David Oleksyn,Michael DeRan,Elise Van Pelt,Joel Shapiro,Ignacio Sanz,Luojing Chen,Jiyong Zhao +8 more
TL;DR: The results of the present study indicate that Ubc13-Uev1A may represent a potential therapeutic target in DLBCL and compounds NSC697923, which inhibits the activity of the ubiquitin-conjugating (E2) enzyme, may be exploited for the development ofDLBCL therapeutic agents.
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DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway
Chuan Su,Guang Gao,Sandra M. Schneider,Christopher E. Helt,Carsten Weiss,Michael A. O'Reilly,Dirk Bohmann,Jiyong Zhao +7 more
TL;DR: It is demonstrated that DNA damage induced by ionizing radiation results in the suppression of phosphorylation of NPAT, an in vivo substrate of cyclin E–Cdk2 kinase and an essential regulator of hist one gene transcription, and its dissociation from histone gene clusters in a p53/p21‐dependent manner.
Journal ArticleDOI
NPAT expression is regulated by E2F and is essential for cell cycle progression.
Guang Gao,Adrian P. Bracken,Karina T. D. Burkard,Diego Pasini,Marie Classon,Claire Attwooll,Masashi Sagara,Takashi Imai,Kristian Helin,Jiyong Zhao +9 more
TL;DR: It is shown that NPAT transcription is up-regulated at the G1/S-phase boundary in growth-stimulated cells and that the NPAT promoter responds to activation by E2F proteins, and that induced expression of E2f1 stimulates NPAT mRNA expression, supporting the idea that the expression of NPAT is regulated by E1F.