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Adrian P. Bracken
Researcher at Trinity College, Dublin
Publications - 61
Citations - 10617
Adrian P. Bracken is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: PRC2 & Chromatin. The author has an hindex of 31, co-authored 56 publications receiving 9652 citations. Previous affiliations of Adrian P. Bracken include European Institute of Oncology & Boston Children's Hospital.
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Journal ArticleDOI
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
TL;DR: The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer are identified using genome-wide location analysis in human embryonic fibroblasts.
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EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer
TL;DR: It is demonstrated that both EZH2 and EED are essential for the proliferation of both transformed and non‐transformed human cells and, in addition, the pRB‐E2F pathway tightly regulates their expression and, consistent with this, it is found that EZh2 is highly expressed in a large set of human tumors.
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Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
TL;DR: It is shown that mice lacking Suz12 are not viable and die during early postimplantation stages displaying severe developmental and proliferative defects, and an essential role of SUZ12 in regulating the activity of the PRC2/3 complexes, which are required for regulating proliferation and embryogenesis.
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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Adrian P. Bracken,Daniela Kleine-Kohlbrecher,Nikolaj Dietrich,Diego Pasini,Gaetano Gargiulo,Chantal Beekman,Kim Theilgaard-Mönch,Saverio Minucci,Bo T. Porse,Jean-Christophe Marine,Klaus Hansen,Kristian Helin +11 more
TL;DR: The ability of the oncogene BMI1 to repress the INK4A-ARF locus requires its direct association and is dependent on the continued presence of the EZH2-containing Polycomb-Repressive Complex 2 (PRC2) complex.
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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
Heiko Muller,Adrian P. Bracken,Richard Vernell,M. Cristina Moroni,Fred Christians,Emanuela Grassilli,Elena Prosperini,Elena Vigo,Jonathan D. Oliner,Kristian Helin +9 more
TL;DR: It is shown that the E2Fs control the expression of several genes that are involved in cell proliferation and apoptosis, differentiation, and development and provide possible genetic explanations to the variety of phenotypes observed as a consequence of a deregulated pRB/E2F pathway.