J
Joana Almeida
Researcher at University of Porto
Publications - 13
Citations - 79
Joana Almeida is an academic researcher from University of Porto. The author has contributed to research in topics: Cancer cell & Cell cycle checkpoint. The author has an hindex of 4, co-authored 13 publications receiving 49 citations.
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High salt intake is associated with a higher risk of cardiovascular events: a 7.2-year evaluation of a cohort of hypertensive patients.
TL;DR: In a cohort of hypertensive patients, high salt intake independently predicts the occurrence of CV events, particularly of stroke.
Journal ArticleDOI
SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner.
Helena Ramos,Juliana Calheiros,Joana Almeida,Valentina Barcherini,Sónia F. G. Santos,Alexandra T. P. Carvalho,Maria M. M. Santos,Lucília Saraiva +7 more
TL;DR: It is unveiled that p53 activation by (S)-tryptophanol-derived oxazoloisoindolinone (SLMP53-1) mediated the reprograming of glucose metabolism in cancer cells and xenograft human tumor tissue, interfering with angiogenesis and migration.
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Comparison Study of Different Extracts of Plectranthus madagascariensis, P. neochilus and the Rare P. porcatus (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities.
Diogo Matias,Marisa Nicolai,Ana Sofia Fernandes,Nuno Saraiva,Joana Almeida,Lucília Saraiva,Célia Faustino,Ana Díaz-Lanza,Catarina Pinto Reis,Catarina Pinto Reis,Patrícia Rijo,Patrícia Rijo +11 more
TL;DR: Medicinal plants of the Plectranthus genus (Lamiaceae) are known for their ethnopharmacological relevance, mainly against infectious, dermatologic and gastrointestinal pathologies, validating the traditional uses of such plants as anti-infectious agents.
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Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness.
TL;DR: A literature review of chalcones and their analogues potentially interfering with the p53 pathway is presented in this paper, where the chalcone binding cleft of MDM2 has been identified as a potential inhibitor of p53-MDM2 interaction.
Journal ArticleDOI
Potency and Selectivity Optimization of Tryptophanol-Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer
Valentina Barcherini,Joana Almeida,Elizabeth A. Lopes,Mi Wang,Diogo Magalhães e Silva,Mattia Mori,Shaomeng Wang,Lucília Saraiva,Maria M. M. Santos +8 more
TL;DR: Binding studies with MDM2 showed that the antiproliferative activity of tryptophanol‐derived isoindolinones does not involve inhibition of the main negative regulator of the p53 protein.