J
Joana Rodrigues
Researcher at University of Coimbra
Publications - 21
Citations - 200
Joana Rodrigues is an academic researcher from University of Coimbra. The author has contributed to research in topics: Computer science & Comparative genomic hybridization. The author has an hindex of 6, co-authored 15 publications receiving 140 citations. Previous affiliations of Joana Rodrigues include Newcastle University.
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Journal ArticleDOI
Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
Luana Naia,Teresa Cunha-Oliveira,Joana Rodrigues,Tatiana R. Rosenstock,Ana Oliveira,Márcio Ribeiro,Catarina Carmo,Sofia I. Oliveira-Sousa,Ana I. Duarte,Michael R. Hayden,A. Cristina Rego +10 more
TL;DR: The results suggest that HDACIs, particularly SB, promote the activity of PDH in the HD brain, helping to counteract HD-related deficits in mitochondrial bioenergetics and motor function.
Journal ArticleDOI
Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells--protective effect of cystamine and creatine.
TL;DR: The results indicate that elevation of the antioxidant systems accompanies mitochondrial-driven ROS generation in mutant striatal cells and that exposure to noxious stimuli induces a higher susceptibility to oxidative stress by increasing XO activity and lowering the antioxidant response.
Journal ArticleDOI
Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin
Luana Naia,Márcio Ribeiro,Joana Rodrigues,Ana I. Duarte,Carla Lopes,Tatiana R. Rosenstock,Michael R. Hayden,A. Cristina Rego +7 more
TL;DR: Differential HD-associated metabolic dysfunction in striatal cell lines and primary cortical cultures, both of which being alleviated by insulin and IGF-1 are demonstrated.
Journal ArticleDOI
Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntington's Disease.
Ana Silva,Luana Naia,Alejandro Dominguez,Márcio Ribeiro,Joana Rodrigues,Otilia V. Vieira,Volkmar Lessmann,Ana Cristina Rego +7 more
TL;DR: The results highlight the importance of BDNF-induced TrkB receptor signaling in rescuing HD-mediated apoptotic features in striatal cells.
Journal ArticleDOI
Paf1 and Ctr9, core components of the PAF1 complex, maintain low levels of telomeric repeat containing RNA.
Joana Rodrigues,David Lydall +1 more
TL;DR: The data suggest that Paf1 and Ctr9 maintain low TERRA levels by affecting both transcription and degradation and that short telomeres in cdc73Δ, paf1Δ and ctr9Δ mutants do not induce TERRA.