S
Sofia I. Oliveira-Sousa
Researcher at University of Coimbra
Publications - 2
Citations - 144
Sofia I. Oliveira-Sousa is an academic researcher from University of Coimbra. The author has contributed to research in topics: Mitochondrion & TFAM. The author has an hindex of 2, co-authored 2 publications receiving 101 citations.
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Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington’s Disease Models
Luana Naia,Tatiana R. Rosenstock,Ana Oliveira,Sofia I. Oliveira-Sousa,Gladys L. Caldeira,Catarina Carmo,Mário N. Laço,Michael R. Hayden,Catarina R. Oliveira,A. Cristina Rego +9 more
TL;DR: Overall, data indicate that activation of deacetylase activity by RESV improved gene transcription associated to mitochondrial function in HD, which may partially control HD-related motor disturbances.
Journal ArticleDOI
Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
Luana Naia,Teresa Cunha-Oliveira,Joana Rodrigues,Tatiana R. Rosenstock,Ana Oliveira,Márcio Ribeiro,Catarina Carmo,Sofia I. Oliveira-Sousa,Ana I. Duarte,Michael R. Hayden,A. Cristina Rego +10 more
TL;DR: The results suggest that HDACIs, particularly SB, promote the activity of PDH in the HD brain, helping to counteract HD-related deficits in mitochondrial bioenergetics and motor function.