C
Catarina Carmo
Researcher at University of Coimbra
Publications - 5
Citations - 324
Catarina Carmo is an academic researcher from University of Coimbra. The author has contributed to research in topics: Mitochondrion & Huntington's disease. The author has an hindex of 5, co-authored 5 publications receiving 202 citations.
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Book ChapterDOI
Mitochondrial Dysfunction in Huntington's Disease.
TL;DR: This chapter resumes some of the evidences that pose mitochondria as a main regulatory organelle in HD-affected neurons, uncovering some potentially therapeutic mitochondrial-based relevant targets.
Journal ArticleDOI
Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington’s Disease Models
Luana Naia,Tatiana R. Rosenstock,Ana Oliveira,Sofia I. Oliveira-Sousa,Gladys L. Caldeira,Catarina Carmo,Mário N. Laço,Michael R. Hayden,Catarina R. Oliveira,A. Cristina Rego +9 more
TL;DR: Overall, data indicate that activation of deacetylase activity by RESV improved gene transcription associated to mitochondrial function in HD, which may partially control HD-related motor disturbances.
Journal ArticleDOI
Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
Luana Naia,Teresa Cunha-Oliveira,Joana Rodrigues,Tatiana R. Rosenstock,Ana Oliveira,Márcio Ribeiro,Catarina Carmo,Sofia I. Oliveira-Sousa,Ana I. Duarte,Michael R. Hayden,A. Cristina Rego +10 more
TL;DR: The results suggest that HDACIs, particularly SB, promote the activity of PDH in the HD brain, helping to counteract HD-related deficits in mitochondrial bioenergetics and motor function.
Journal ArticleDOI
Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics.
Luana Naia,Catarina Carmo,Susanna Campesan,Lígia Fão,Victoria E. Cotton,Jorge Valero,Carla Lopes,Tatiana R. Rosenstock,Flaviano Giorgini,A. Cristina Rego +9 more
TL;DR: It is shown that SIRT3 is neuroprotective in Huntington's disease (HD), a motor neurodegenerative disorder caused by an abnormal expansion of polyglutamines in the huntingtin protein (HTT), and a link between oxidative stress and mitochondrial dysfunction hypotheses in HD is provided.
Book ChapterDOI
Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington's Disease.
TL;DR: This chapter describes some methodologies used to study mitochondrial function by determining the oxygen consumption, changes in Δψ m, mitochondrial calcium handling, and levels of mitochondrial ROS.